AI Article Synopsis
- People with frailty have a higher risk of developing atrial fibrillation (AF), and this study aimed to investigate how long-term changes in frailty influence this risk.
- The study involved over 50,000 UK Biobank participants who were assessed on their frailty levels and monitored for new cases of AF, heart failure (HF), coronary heart disease (CHD), and stroke over approximately 5 years.
- Results indicated that even small increases in frailty (ΔFI) significantly raised the risk of AF, and participants who remained frail had nearly double the risk compared to those who maintained non-frail status; however, those who improved their frailty status saw a notable decrease in risk.
Article Abstract
Background: People with frailty have increased prevalence and incidence of atrial fibrillation (AF).
Objective: The study aimed to further investigate the association of long-term changes in frailty with risk of new-onset AF. Its associations with heart failure (HF), coronary heart disease (CHD), and stroke were also evaluated as a secondary aim.
Methods: Over 50,000 participants from UK Biobank cohort were included, with frailty index (FI) data and free of AF, HF, CHD or stroke in baseline and follow-up assessments. Frailty status of the participants was categorized into non-frail, pre-frail and frail based on their FI scores. FI in baseline and follow-ups are used to calculate the trajectories of frailty (ΔFI).
Results: During a median of 5.1 years of follow-up from the final assessment, 1729 cases of AF were recorded. Frailty trajectory analysis showed that even a 0.01 point/year increase in ΔFI was associated with 14% (95% CI 1.08-1.20) higher risk of AF, independent of baseline FI after adjusting for potential confounders. Compared with maintained non-frail participants, those with sustained frail status had the highest risk of incident AF (HR 1.95, 1.61-2.36). The risk declined by 30% (95% CI 0.53-0.94) when frail participants regressed to non-frail or pre-frail status, compared with sustained frail participants. These associations were similar in HF and CHD, however, not significant in stroke.
Conclusion: In middle-aged and elderly individuals, frailty remission or non-frailty maintenance was associated with lower risk of AF, HF and CHD compared to persistent frailty, regardless of prior frailty status and established risk factors.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.hrthm.2025.01.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Continuous Fragility Index of Statistically Significant Findings in Studies Based on High Levels of Evidence Comparing Interventions for Femoroacetabular Impingement Syndrome.
Am J Sports Med
January 2025
Department of Orthopaedics, Rush University Medical Center, Rush University Medical College, Chicago, Illinois, USA.
Background: Critical analysis of studies with high level of evidence has relied on the significance set by the reported values. However, this strategy steers readers toward categorical interpretation of the data; therefore, a more comprehensive approach of data analysis is warranted. The continuous fragility index (CFI) allows for frailty interpretation of any given study's continuous outcome results.
View Article and Find Full Text PDFSurvival parametric modeling for patients with heart failure based on Kernel learning.
BMC Med Res Methodol
January 2025
Department of Computer Science and Engineering, School of Electrical and Computer Engineering, Shiraz University, Shiraz, Iran.
Time-to-event data are very common in medical applications. Regression models have been developed on such data especially in the field of survival analysis. Kernels are used to handle even more complicated and enormous quantities of medical data by injecting non-linearity into linear models.
View Article and Find Full Text PDFThe Surgical Pause: The Importance of Measuring Frailty and Taking Action to Address Identified Frailty.
Jt Comm J Qual Patient Saf
November 2024
Conceptual Framework: The Surgical Pause is a rapid, scalable strategy for health care systems to optimize perioperative outcomes for high-risk, frail patients considering elective surgery. The first and most important step is to screen for frailty, thereby identifying the 5% to 10% of patients at most risk for postoperative complications, loss of independence, institutionalization, and mortality. The second step is to take action to improve outcomes.
View Article and Find Full Text PDFLoss of Insight in Syndromes Associated with Frontotemporal Lobar Degeneration: Clinical and Imaging Features.
Am J Geriatr Psychiatry
December 2024
Department of Clinical and Experimental Sciences (DA, BB), University of Brescia, Brescia, Italy; Molecular Markers Laboratory (BB), IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. Electronic address:
Objectives: The present study aims to assess the prevalence, associated clinical symptoms, longitudinal changes, and imaging correlates of Loss of Insight (LOI), which is still unexplored in syndromes associated with Frontotemporal Lobar Degeneration (FTLD).
Design: Retrospective longitudinal cohort study, from Oct 2009 to Feb 2023.
Setting: Tertiary Frontotemporal Dementia research clinic.
Long-term changes in frailty and incident atrial fibrillation, heart failure, coronary heart disease, and stroke: A prospective follow-up study.
Heart Rhythm
January 2025
Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. Electronic address:
Article Synopsis
- People with frailty have a higher risk of developing atrial fibrillation (AF), and this study aimed to investigate how long-term changes in frailty influence this risk.
- The study involved over 50,000 UK Biobank participants who were assessed on their frailty levels and monitored for new cases of AF, heart failure (HF), coronary heart disease (CHD), and stroke over approximately 5 years.
- Results indicated that even small increases in frailty (ΔFI) significantly raised the risk of AF, and participants who remained frail had nearly double the risk compared to those who maintained non-frail status; however, those who improved their frailty status saw a notable decrease in risk.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!