Left posterior superior temporal gyrus and its structural connectivity in schizophrenia.

The left posterior superior temporal gyrus (pSTG) is thought to be involved in the pathophysiology and core symptoms of schizophrenia, although its structural connectivity has not yet been systematically investigated. Here, we aimed to evaluate its white matter (WM) connectivity with Broca's area, the thalamus, and the right pSTG. Eighty-three patients with schizophrenia and 141 healthy controls underwent diffusion-weighted imaging and T1-weighted three-dimensional magnetic resonance imaging. Probabilistic tractography was performed from the left pSTG to the Broca area, the left thalamus, and the right pSTG. Group comparison of WM fractional anisotropy (FA) in these pathways, as well as its correlations with the pSTG volume and clinical characteristics in the patient group, were examined. Patients showed significantly lower FA in the left pSTG-Broca and left-right pSTG pathways, but not in the left pSTG-thalamus pathway. Patients also revealed a trend toward a smaller left pSTG volume. Significant negative correlations were found in patients between FA in the left-right pSTG pathway and the left pSTG volume, and between FA in the left pSTG-Broca pathway and positive symptom severity. The present results suggest fiber-specific alterations in structural connectivity linked to the left pSTG, possibly supporting the "inner speech" and "interhemispheric disconnection" hypotheses of schizophrenia.