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| http://dx.doi.org/10.3390/jcm14010226 | DOI Listing |
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Correction: Bouchard et al. A Multisite Non-Inferiority Randomized Controlled Trial of the Efficacy of Cognitive-Behavior Therapy for Generalized Anxiety Disorder Delivered by Videoconference. 2022, , 5924.
J Clin Med
January 2025
Département de Psychologie, Université du Québec à Montréal, Montréal, QC H2L 2C4, Canada.
In the original publication [...
View Article and Find Full Text PDF[Correcting pathogenic mutations using prime editing: an overview].
Med Sci (Paris)
October 2024
Département de médecine moléculaire, Université Laval, Québec, Canada - Centre de recherche du CHU de Québec, Université Laval, Québec, Canada.
Gene editing is an ever-evolving field and Prime editing technology is among the latest ones. It makes it possible to modify a gene using a Cas9 nickase that cuts a single strand of DNA. This Cas9 nickase is fused with a reverse transcriptase that copies a single guide RNA synthetized by the researcher.
View Article and Find Full Text PDFEpigenome-wide meta-analysis of prenatal vitamin D insufficiency and cord blood DNA methylation.
Epigenetics
December 2024
Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Article Synopsis
- Low maternal vitamin D levels during pregnancy have been linked to various health issues in offspring and may affect DNA methylation, a process that influences gene expression.
- The study examined the relationship between maternal vitamin D insufficiency (defined as less than 75 nmol/L) and DNA methylation patterns in the cord blood of newborns using data from 3738 mother-child pairs across seven cohorts.
- Despite a significant prevalence of vitamin D insufficiency among the mothers (ranging from 44.3% to 78.5%), the research found no significant association between maternal vitamin D levels and DNA methylation at the analyzed sites after adjusting for various factors.
Associations of gut microbiota features and circulating metabolites with systemic inflammation in children.
BMJ Open Gastroenterol
August 2024
Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
Objective: Gut microbes and microbe-dependent metabolites (eg, tryptophan-kynurenine-serotonin pathway metabolites) have been linked to systemic inflammation, but the microbiota-metabolite-inflammation axis remains uncharacterised in children. Here we investigated whether gut microbiota features and circulating metabolites (both microbe-dependent and non-microbe-dependent metabolites) associated with circulating inflammation markers in children.
Methods: We studied children from the prospective Gen3G birth cohort who had data on untargeted plasma metabolome (n=321 children; Metabolon platform), gut microbiota (n=147; 16S rRNA sequencing), and inflammation markers (plasminogen activator inhibitor-1 (PAI-1), monocyte chemoattractant protein-1, and tumour necrosis factor-α) measured at 5-7 years.
Author Correction: BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets.
Nat Methods
October 2024
Institute for Brain and Intelligence, Southeast University, Nanjing, China.
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