Myopia is one of the dominant causes of visual impairment in the world. Pathological myopia could even lead to other serious eye diseases. Researchers have reached a consensus that myopia could be caused by both environmental and genetic risk factors. Exploring the pathological mechanism of myopia can provide a scientific basis for developing measures to delay the progression of myopia or even treat it. Recent advances highlight that scleral hypoxia could be an important factor in promoting myopia. In this review, we summarized the role of scleral hypoxia in the pathology of myopia and also provided interventions for myopia that target scleral hypoxia directly or indirectly. We hope this review will aid in the development of novel therapeutic strategies and drugs for myopia.
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An Evidence-Based Narrative Review of Scleral Hypoxia Theory in Myopia: From Mechanisms to Treatments.
Int J Mol Sci
January 2025
College of Physical Education, Hunan Normal University, Changsha 410012, China.
Myopia is one of the dominant causes of visual impairment in the world. Pathological myopia could even lead to other serious eye diseases. Researchers have reached a consensus that myopia could be caused by both environmental and genetic risk factors.
View Article and Find Full Text PDFMolecular mechanism of hypoxia and alpha-ketoglutaric acid on collagen expression in scleral fibroblasts.
Int J Ophthalmol
October 2024
School of Life Science and Technology, Shandong Second Medical University, Weifang 261053, Shandong Province, China.
Aim: To investigate the molecular mechanisms underlying the influence of hypoxia and alpha-ketoglutaric acid (α-KG) on scleral collagen expression.
Methods: Meta-analysis and clinical statistics were used to prove the changes in choroidal thickness (ChT) during myopia. The establishment of a hypoxic myopia model (HYP) for rabbit scleral fibroblasts through hypoxic culture and the effects of hypoxia and α-KG on collagen expression were demonstrated by Sirius red staining.
Impact of Acute Short-term Hypobaric Hypoxia on Anterior Chamber Geometry.
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Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China, 100730.
Article Synopsis
- Hypobaric hypoxia, a condition at high altitudes, causes pupil constriction and expands the anterior chamber angle, possibly safe for those with narrow angles, necessitating further examination.
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The central and peripheral corneal response to short-term hypoxia.
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Contact Lens and Visual Optics Laboratory, Optometry and Vision Science, Centre for Vision and Eye Research, Queensland University of Technology, Brisbane, Queensland, Australia.
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Investigation roles of Adamts1 and Adamts5 in scleral fibroblasts under hypoxia and mice with form-deprived myopia.
Exp Eye Res
October 2024
Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, 253 Gongye Middle Avenue, Guangzhou, 510280, GuangDong, China. Electronic address:
Article Synopsis
- Scleral hypoxia is linked to myopia by causing changes in the sclera, and understanding this involves identifying key molecules.
- Researchers developed a hypoxia model and used RNA sequencing to find that Adamts1 and Adamts5 genes are upregulated in hypoxic scleral fibroblasts, which correlates with decreased COLLAGEN I levels.
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