AI Article Synopsis
- The esters of 3H-2-imino-7-methyl-4-oxopyrido [3,2-e]-1,3-thiazine-5- and -6-carboxylic acids undergo the Mannich reaction to produce 3-aminomethyl derivatives.
- Derivatives of ester II showed significant analgesic and antiserotonic properties.
- Compounds generated from this reaction could have potential therapeutic applications due to their observed activities.
Article Abstract
It was stated that esters of 3H-2-imino-7-methyl-4-oxopyrido [3,2-e]-1,3-thiazine-5- and -6-carboxylic acids (I, II) undergo the Mannich reaction giving the corresponding 3-aminomethyl derivatives (III-XIV). Derivatives of ester II [(XII) and (XIV)] showed distinct analgesic and antiserotonic activities.
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| http://dx.doi.org/10.1002/chin.198523233 | DOI Listing |
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