AI Article Synopsis
- The study highlights the potential of marine natural products as a resource for pharmaceuticals, focusing on a bacterium (S-1) found in shallow sea sediments.
- Researchers isolated a novel compound (4-(dimethylamino)-1-(2-((4-hydroxybenzoyl)oxy)propyl)pyridin-1-ium) and 15 known cyclic dipeptides from S-1, using NMR and optical rotation for structural analysis.
- The novel compound demonstrated antibacterial activity with a minimum inhibitory concentration (MIC) of 50 µg/mL, marking it as the first discovered pyridinium derivative and cyclic dipeptides from this marine source.
Article Abstract
The structural diversity of marine natural products is considered a potential resource for the pharmaceutical industry. In our study of marine-derived compounds, one bacterium S-1 was discovered to have the ability to produce bioactive natural products. After a further chemistry investigation, one novel 4-aminopyridinium derivative, 4-(dimethylamino)-1-(2-((4hydroxybenzoyl)oxy)propyl)pyridin-1-ium (), along with 15 known cyclic dipeptides (-) were isolated from the bacterium S-1 derived from a shallow sea sediment. The structures of compounds - were elucidated through comprehensive NMR spectroscopic and specific optical rotation (OR) data analyses. Compound showed antibacterial activity against with an MIC value of 50 µg/mL. This is the first study to discover a pyridinium derivative and cyclic dipeptides from
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Article Synopsis
- The study highlights the potential of marine natural products as a resource for pharmaceuticals, focusing on a bacterium (S-1) found in shallow sea sediments.
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- The novel compound demonstrated antibacterial activity with a minimum inhibitory concentration (MIC) of 50 µg/mL, marking it as the first discovered pyridinium derivative and cyclic dipeptides from this marine source.
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