Adopting GPR75 in treating obesity: unraveling the knowns and unknowns of this orphan GPCR.

Trends Cell Biol

Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

Published: January 2025

G protein-coupled receptor 75 (GPR75) is emerging as a promising target for obesity treatment, but its exact role in energy regulation remains unclear. This article explores the latest research on GPR75's molecular function, potential ligands, and therapeutic challenges in addressing obesity.

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http://dx.doi.org/10.1016/j.tcb.2024.12.006DOI Listing

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