Widening research horizons on metabolic dysfunction-associated steatotic liver disease and cancer.

Trends Endocrinol Metab

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.

Published: January 2025

AI Article Synopsis

  • Liver fibrosis and biological sex influence the likelihood of developing hepatocellular carcinoma (HCC) and extrahepatic cancers (EHCs) in people with metabolic dysfunction-associated steatotic liver disease (MASLD).
  • The differences in cancer risk based on these factors suggest the need for tailored chemoprevention and precision medicine strategies in treating MASLD.
  • This understanding calls for more research to explore how these variables can inform better treatment approaches.

Article Abstract

Liver fibrosis and biological sex variably modulate the risks of hepatocellular carcinoma (HCC) and extrahepatic cancers (EHCs) arising in the context of metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we highlight how these variables may have implications in the setting of chemoprevention and precision medicine approaches in MASLD and guide additional research.

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Source
http://dx.doi.org/10.1016/j.tem.2024.12.009DOI Listing

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