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Background: Mental health remains among the top 10 leading causes of disease burden globally, and there is a significant treatment gap due to limited resources, stigma, limited accessibility, and low perceived need for treatment. Problem Management Plus, a World Health Organization-endorsed brief psychological intervention for mental health disorders, has been shown to be effective and cost-effective in various countries globally but faces implementation challenges, such as quality control in training, supervision, and delivery. While digital technologies to foster mental health care have the potential to close treatment gaps and address the issues of quality control, their development requires context-specific, interdisciplinary, and participatory approaches to enhance impact and acceptance.
View Article and Find Full Text PDFQuantum life science: biological nano quantum sensors, quantum technology-based hyperpolarized MRI/NMR, quantum biology, and quantum biotechnology.
Chem Soc Rev
January 2025
Institute for Quantum Life Science, National Institutes for Quantum Science and Technology (QST), Anagawa 4-9-1, Inage-ku, Chiba 263-8555, Japan.
The emerging field of quantum life science combines principles from quantum physics and biology to study fundamental life processes at the molecular level. Quantum mechanics, which describes the properties of small particles, can help explain how quantum phenomena such as tunnelling, superposition, and entanglement may play a role in biological systems. However, capturing these effects in living systems is a formidable challenge, as it involves dealing with dissipation and decoherence caused by the surrounding environment.
View Article and Find Full Text PDFManipulating the interfacial integration mode of a bio-templated porous ZSM-5 platform with an Au/CuZnO catalyst for enhanced efficiency and recycling stability in glycerol conversion to 1,3-dihydroxyacetone.
Nanoscale
January 2025
School of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, PR China.
Despite the potential to significantly enhance the economic viability of biomass-based platforms through the selective conversion of glycerol to 1,3-dihydroxyacetone (DHA), a formidable challenge persists in simultaneously achieving high catalytic activity and stability along this reaction pathway. Herein, we have devised a strategic approach to manipulate the interfacial integration within composite catalysts to address the performance trade-off. Through the modulation of the composite process involving a bio-templated porous ZSM-5 zeolite platform (bZ) and an Au/CuZnO catalyst, three distinct interfacial bonding modes were achieved: physical milling, encapsulation by zeolite, and growth on zeolite.
View Article and Find Full Text PDFThe Role of Tumor-Associated Neutrophils in Early Luminal HER2-Negative Breast Cancer Progression.
Asian Pac J Cancer Prev
January 2025
D1 S.P. Botkin City Clinical Hospital, Moscow, Russia.
Objectives: To study the predictive role of tumor-associated neutrophils in early luminal HER2-negative breast cancer.
Materials And Methods: This is a retrospective study conducted on 60 women cases aged from 31 to 79 years underwent surgery for luminal HER2-negative ductal breast cancer in tertiary care cancer centre. We first estimated basic morphological signs: tumor size, tumor grade (by Nottingham Histologic Score), tumor infiltrating lymphocytes (TILs), Lymphovascular invasion, hormonal receptors status, proliferative index, and regional lymph nodes metastasis.
The role of circular RNAs in autoimmune diseases: Potential diagnostic biomarkers and therapeutic targets.
FASEB J
January 2025
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
With the emergence of high-quality sequencing technologies, further research on transcriptomes has become possible. Circular RNA (circRNA), a novel type of endogenous RNA molecule with a covalently closed circular structure through "back-splicing," is reported to be widely present in eukaryotic cells and participates mainly in regulating gene and protein expression in various ways. It is becoming a research hotspot in the non-coding RNA field.
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