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Improving Understanding of Fexofenadine Pharmacokinetics to Assess Pgp Phenotypic Activity in Older Adult Patients Using Population Pharmacokinetic Modeling.
Clin Pharmacokinet
January 2025
Clinical Pharmacology and Toxicology Service, Anesthesiology, Pharmacology and Intensive Care Department, Geneva University Hospitals, 4 Rue Gabrielle Perret-Gentil, 1205, Geneva, Switzerland.
Background And Objective: Fexofenadine is commonly used as a probe substrate to assess P-glycoprotein (Pgp) activity. While its use in healthy volunteers is well documented, data in older adult and polymorbid patients are lacking. Age- and disease-related physiological changes are expected to affect the pharmacokinetics of fexofenadine.
View Article and Find Full Text PDFBest Practice Recommendations for Endometrial Intraepithelial Neoplasia/Atypical Endometrial Hyperplasia in the Military Health System.
Mil Med
January 2025
Division of Gynecologic Oncology, Department of Gynecologic Surgery & Obstetrics, Tripler Army Medical Center, Honolulu, HI 96859, USA.
Endometrial cancer is the most prevalent gynecologic cancer in the United States and has rising incidence and mortality. Endometrial intraepithelial neoplasia or atypical endometrial hyperplasia (EIN-AEH), a precancerous neoplasm, is surgically managed with hysterectomy in patients who have completed childbearing because of risk of progression to cancer. Concurrent endometrial carcinoma (EC) is also present on hysterectomy specimens in up to 50% of cases.
View Article and Find Full Text PDFA 6D Object Pose Estimation Algorithm for Autonomous Docking with Improved Maximal Cliques.
Sensors (Basel)
January 2025
Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China.
Accurate 6D object pose estimation is critical for autonomous docking. To address the inefficiencies and inaccuracies associated with maximal cliques-based pose estimation methods, we propose a fast 6D pose estimation algorithm that integrates feature space and space compatibility constraints. The algorithm reduces the graph size by employing Laplacian filtering to resample high-frequency signal nodes.
View Article and Find Full Text PDFDetection Method for Bolt Loosening Based on Summation Coefficient of Absolute Spectrum Ratio.
Sensors (Basel)
January 2025
Fujian Provincial Key Laboratory of Terahertz Functional Devices and Intelligent Sensing, School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou 350108, China.
A bolt loosening detection method based on the summation coefficient of the absolute spectrum ratio technique is proposed to address the prevalent issue of bolt loosening in mechanical connections. This proposed method involves initially collecting vibration and rotation speed signals of the motor bolt connection structure, acquiring the baseline spectrum curve of a healthy structure and the spectrum curves of non-healthy structures under different degrees of bolt looseness through chirp Fourier transform (CFT). Subsequently, the spectrum ratio curves between healthy and non-healthy structures are calculated for different degrees of bolt loosening, and then the Summation Coefficient of Absolute Spectrum Ratio (SCASR) is defined to indicate the looseness.
View Article and Find Full Text PDFGeotechnical Assessment of Foundation Stability for Preserving the Agrippa Monument at the Acropolis of Athens.
Sensors (Basel)
January 2025
Acropolis Restoration Service, Hellenic Ministry of Culture, 10555 Athens, Greece.
This study focuses on the geotechnical evaluation of the foundation conditions of the Agrippa Monument at the Acropolis of Athens, aiming to propose interventions to improve stability and reduce associated risks. The assessment reveals highly uneven foundation conditions beneath the monument. A thorough collection of bibliographic references and geotechnical surveys was conducted, classifying geomaterials into engineering-geological units and evaluating critical parameters for geotechnical design.
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