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Iron Chelation Prevents Age-Related Skeletal Muscle Sarcopenia in Klotho Gene Mutant Mice, a Genetic Model of Aging.
J Cachexia Sarcopenia Muscle
February 2025
Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA.
Background: A decline in skeletal muscle mass and function known as skeletal muscle sarcopenia is an inevitable consequence of aging. Sarcopenia is a major cause of decreased muscle strength, physical frailty and increased muscle fatigability, contributing significantly to an increased risk of physical disability and functional dependence among the elderly. There remains a significant need for a novel therapy that can improve sarcopenia and related problems in aging.
View Article and Find Full Text PDFAssessment of Iron Metabolism and Inflammation in Children with Cerebral Palsy.
J Clin Med
December 2024
Department of Physiology, Faculty of Medicine, Mardin Artuklu University, Mardin 47100, Turkey.
Cerebral palsy (CP) is a motor disorder resulting from brain damage that is common in childhood. Iron is vital for the body's basic functions. Iron metabolism disorders and inflammation contribute to the neurological complications seen in CP.
View Article and Find Full Text PDFAssessing the Nutrient Composition of a Carnivore Diet: A Case Study Model.
Nutrients
December 2024
Human Potential Centre, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 0632, New Zealand.
Background/objectives: The rise in chronic metabolic diseases has led to the exploration of alternative diets. The carnivore diet, consisting exclusively of animal products, has gained attention, anecdotally, for imparting benefit for inflammatory conditions beyond that possible by other restrictive dietary approaches. The aim was to assess the micronutrient adequacy of four versions of the carnivore diet against national nutrient reference values (NRVs).
View Article and Find Full Text PDFAmino Acid Profile and Mineral Content of Cultivated Snails and : Assessing Their Potential as Nutritional Source.
Foods
January 2025
Agriculture Science and Technology Research Institute, Andong National University, Andong 36729, Republic of Korea.
This study evaluates the nutritional potential of two cultivated snail species, and , sourced from commercial farms in Korea, marking the first comprehensive analysis of . The protein content of (70.9 g/100 g dry matter) was significantly higher than that of (44.
View Article and Find Full Text PDFCooperative and Independent Functionality of tmRNA and SmpB in : A Multifunctional Exploration Beyond Ribosome Rescue.
Int J Mol Sci
January 2025
Pathogenesis and Control of Pathogenic Microorganisms Research Team, School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou 570228, China.
The trans-translation system, mediated by transfer-messenger RNA (tmRNA, encoded by the gene) and its partner protein SmpB, helps to release ribosomes stalled on defective mRNA and targets incomplete protein products for hydrolysis. Knocking out the and genes in various pathogens leads to different phenotypic changes, indicating that they have both cooperative and independent functionalities. This study aimed to clarify the functional relationships between tmRNA and SmpB in a pathogen that poses threats in aquaculture and human health.
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