AI Article Synopsis
- Benzene exposure is linked to an increased risk of stroke, with a 70% rise in risk for every 1 μg/m increase in concentration.
- The study analyzed data from over 13,000 stroke patients and 377,000 controls to assess the relationship between benzene and stroke risk, also considering genetic factors through a polygenic risk score (PRS).
- High benzene exposure combined with a high PRS resulted in a 44% greater stroke risk, suggesting that both environmental and genetic factors contribute to the association, potentially through accelerated biological aging.
Article Abstract
Benzene can cause respiratory diseases. However, the associations between benzene and stroke are unclear. A total of 13,116 patients with stroke and 377,120 controls from the UK Biobank were included. The benzene exposure concentrations were matched on the basis of the address information of each participant via a data form from the UK Department for Environment, Food and Rural Affairs. Weighted Cox regression was used to investigate the association between benzene and stroke risk. The polygenic risk score (PRS) was used to observe the joint effects of benzene exposure and genetic factors on stroke risk. We conducted a mediation analysis to investigate the mediating role of accelerated biological aging in this cohort study. After adjusting for covariates, every 1 μg/m increase in benzene exposure increased the risk of stroke by 70%, which may be mediated by accelerated biological aging. The population with high benzene exposure concentrations and high PRSs had a 44% greater risk of stroke than did those with low benzene exposure concentrations and low PRSs. Benzene exposure and the PRS have joint effects on the risk of stroke. Benzene exposure was associated with stroke risk, possibly through increased biological aging, and the PRS modified this association.
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| http://dx.doi.org/10.1016/j.envpol.2025.125656 | DOI Listing |
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