In order to improve the understanding foot function in the presence of planovalgus foot deformity, functional joint center determination is applied to the ankle and midfoot for application in 3D-gait analysis. Gait data of 36 patients with planovalgus (PV) foot deformity as well as of 33 typically developing (TD) subjects were collected using foot markers according to the Heidelberg Foot Measurement method. During single-limb stance subjects performed a circular movement of the foot and ankle (CIR) by drawing a circle with the hallux in the air. Midfoot joint center location as well as kinematics was calculated based (a) on functional calibration, (b) via a simple midpoint approach, and (c) via linear regression. All typically developing participants were able to perform the CIR movement with sufficient ROM for calibration whereas 10 % of the participants with idiopathic PV foot deformity and 72 % of the participants with a neurogenic PV foot were not able to perform this movement adequately. Nevertheless, the regression approach led to almost the same location of the midfoot joint center compared to the functional method with similar kinematics. PV feet show substantially larger Forefoot/Hindfoot flexion and Forefoot/Hindfoot adduction in gait compared to TD feet. On top, feet with neurologic background show reduced ROM of these angles in gait. The CIR movement task may prove useful in future studies monitoring active ranges of ankle and midfoot motion since the kinematics of this task may also be directly assessed via the proposed regression approach.
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http://dx.doi.org/10.1016/j.jbiomech.2025.112493 | DOI Listing |
Front Biosci (Landmark Ed)
January 2025
Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, Henan, China.
Front Biosci (Landmark Ed)
January 2025
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Fujian Medical University, Fujian Provincial Key Laboratory of Stomatology, National Regional Medical Center, Binhai Campus of The First Affiliated Hospital, 350005 Fuzhou, Fujian, China.
Background: In this study, we prepared a porous gradient scaffold with hydroxyapatite microtubules (HAMT) and chitosan (CHS) and investigated osteogenesis induced by these scaffolds.
Methods: The arrangement of wax balls in the mold can control the size and distribution of the pores of the scaffold, and form an interconnected gradient pore structure. The scaffolds were systematically evaluated and for biocompatibility, biological activity, and regulatory mechanisms.
Front Biosci (Landmark Ed)
January 2025
HUN-REN-SZTE Neuroscience Research Group, Hungarian Research Network, University of Szeged (HUN-REN-SZTE), Danube Neuroscience Research Laboratory, H-6725 Szeged, Hungary.
Backgrounds: Memory and emotion are especially vulnerable to psychiatric disorders such as post-traumatic stress disorder (PTSD), which is linked to disruptions in serotonin (5-HT) metabolism. Over 90% of the 5-HT precursor tryptophan (Trp) is metabolized via the Trp-kynurenine (KYN) metabolic pathway, which generates a variety of bioactive molecules. Dysregulation of KYN metabolism, particularly low levels of kynurenic acid (KYNA), appears to be linked to neuropsychiatric disorders.
View Article and Find Full Text PDFExpert Opin Biol Ther
January 2025
State Key Laboratory of Respiratory Disease, Joint International Research Laboratory of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
Introduction: Clinical experience with anti-interleukin (IL)-5 biologic therapies for severe asthma has been increasing, alongside deeper and broader research focusing on the role of IL-5 and the IL-5 targeted mepolizumab. This review aims to provide an update of the evidence on the role of IL-5 and mepolizumab, with discussions of the benefits of mepolizumab and its future potential, to promote the comprehension of the pathophysiology and therapeutic approaches to asthma.
Areas Covered: For this narrative review, we conducted a database search in PubMed and Embase using the keywords 'IL-5' and 'mepolizumab,' focusing on randomized controlled trials and real-world studies up to September 2024.
Foot Ankle Int
January 2025
Division of Foot and Ankle, Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, USA.
Background: Hallux valgus (HV) is a complex, multiplanar deformity. In this study, we examined the interrelationships between various components of this deformity using weightbearing computed tomography (WBCT). We hypothesized that the severity of traditional axial plane deformities would correlate with malpositioning of the metatarsosesamoid complex, first-ray coronal rotational deformity, and malalignment of the hindfoot and midfoot.
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