Objective: OnabotulinumtoxinA (BTA) injections are useful for treatment of myofascial pelvic pain. Concurrent pudendal nerve block (PNB) has been suggested to decrease postoperative pain, as BTA does not take an immediate effect. The efficacy of PNB for this purpose has not been well elucidated. We aim to determine if PNB improves pain in the postoperative period following pelvic floor BTA injections.
Design: A subgroup analysis was performed from a retrospective cohort study including 202 patients encompassing 416 BTA injections at a single high volume, academic institution. Post Anesthesia Care Unit (PACU) visual analog scale (VAS) pain score and oral morphine equivalents (OME) data between 2018 and 2022 were reviewed.
Results: A total of 64 patients met inclusion criteria, encompassing 96 BTA injection events. Thirty-three BTA injections were done with concurrent PNB (BTA/PNB), while 63 injections were performed without PNB (BTA). Demographics of patients were similar in both groups. Mean VAS upon discharge from PACU was 1.7 for BTA alone and 1.9 for BTA/PNB (p = 0.610). Mean time (minutes) in PACU was 100.7 for BTA alone and 100.5 for BTA/PNB (p = 0.692). Mean OMEs given in PACU were 12.5 for BTA alone and 15.0 for BTA/PNB (p = 0.443).
Conclusion: This study may suggest a limited benefit of PNB at improving postoperative pain following pelvic floor BTA injection. Additional research is needed to determine the efficacy of PNB at time of pelvic floor BTA injections.
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http://dx.doi.org/10.1016/j.ejogrb.2024.12.055 | DOI Listing |
Eur J Obstet Gynecol Reprod Biol
January 2025
Department of Medical and Surgical Gynecology, Mayo Clinic Florida, Jacksonville, FL, USA.
Objective: OnabotulinumtoxinA (BTA) injections are useful for treatment of myofascial pelvic pain. Concurrent pudendal nerve block (PNB) has been suggested to decrease postoperative pain, as BTA does not take an immediate effect. The efficacy of PNB for this purpose has not been well elucidated.
View Article and Find Full Text PDFCureus
December 2024
Anatomy, Yonsei University, Seoul, KOR.
Introduction: To date, no investigations have been published regarding the concentration, dose, and technique for a mucosal spray application of botulinum toxin A (BTA) to alleviate hypersecretory symptoms of rhinitis in humans. It is a promising option for reducing common symptoms of seasonal allergic rhinitis (AR) and idiopathic non-AR. It is safer and less painful than intranasal injections, with high reported satisfaction in reducing clinical symptoms.
View Article and Find Full Text PDFRehabilitacion (Madr)
January 2025
University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, Department of Physical Medicine and Rehabilitation, Istanbul, Turkey.
Objective: Spasticity developing in the upper extremity in stroke patients causes disability by limiting movement and causing pain. This study investigates the effects of botulinum toxin injections on pain, functionality, spasticity, and range of motion in hemiplegic patients with post-stroke spasticity.
Materials And Methods: The study involved a double-blind, prospective, randomized controlled trial with thirty-one stroke patients aged 35-80 who developed upper extremity spasticity.
Clin Endosc
November 2024
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
The administration of botulinum toxin A (BTA) into the gastric wall has emerged as a novel endoscopic bariatric procedure. Although over 20 years have elapsed since the initial human trial of intragastric BTA injection, considerable debate remains surrounding the safety, efficacy, and procedural instructions of this approach. The current literature exhibits discrepancies in the methodologies employed across studies, including differences in the dosage of BTA administered, injection site, number and depth of injections, post-procedural dietary modifications, and follow-up duration.
View Article and Find Full Text PDFPLoS One
December 2024
Department of Rehabilitation Medicine, Zibo Central Hospital, Zibo, Shandong, China.
Objective: The purpose of this meta-analysis was to evaluate the therapeutic efficacy and safety of botulinum toxin A (BTA) injections for treatment of plantar fasciitis (PF).
Methods: This review adhered to the PRISMA guidelines, conducting a comprehensive search of the PubMed, Web of Science, EMBASE, and Cochrane Library databases for eligible studies from their inception to December 30 2023. The inclusion criteria were limited to randomized controlled trials (RCTs) comparing BTA injections with control interventions in terms of pain reduction, functional improvement, or the occurrence of adverse events in treating patients with PF were extracted for meta-analysis.
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