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Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), The Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China; Institute of Molecular Medicine (IMM), Renji Hospital, Shanghai Jiao Tong University School of Medicine, College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address:
Article Synopsis
- NAD(H) is crucial for cellular metabolism, and accurately measuring it helps understand biological processes and diseases.
- Researchers developed an electrochemical biosensor using a specific aptamer (NAD3-1a) that can accurately detect NAD(H) at low concentrations with great sensitivity and stability.
- The biosensor revealed significant differences in NAD(H) levels between normal cells and tumor cells, as well as a decrease in aged mice, showing its potential for studying metabolic changes in health and disease.
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