Purpose: Investigate the effect of structured neonatal physical therapy program (SNP) on neurodevelopmental outcomes of moderate and late preterm (MLP) infants.
Methods: Sixty MLP infants were randomly allocated to usual care (UC) or SNP. A previous publication reported the effect of neonatal component of SNP at hospital discharge. This paper examined SNP's effect on motor, cognitive and language outcomes at 3 and 6 months using a 2-way mixed design ANOVA.
Results: Both groups were similar at baseline for motor scores. Infants receiving SNP significantly outperformed UC at all subsequent time points. At 3 and 6 months, SNP significantly outscored UC in cognitive and language outcomes.
Conclusion: SNP is effective in improving neurodevelopmental outcomes of MLP infants. However, caution is suggested in interpreting its effect on cognition and language as we lacked baseline scores to compare the longitudinal trajectory.
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http://dx.doi.org/10.1097/PEP.0000000000001181 | DOI Listing |
Pediatr Phys Ther
January 2025
Department of Physical Therapy, Ellmer College of Health Sciences, Macon & Joan Brock Virginia Health Sciences, Old Dominion University, Norfolk, Virginia (Dr Khurana); Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India (Dr Lewis); School of Exercise Science, Old Dominion University, Norfolk, Virginia (Dr Russell); Sykes Chair of Pediatric Physical Therapy, Health, and Development, University of Southern California, Division of Biokinesiology and Physical Therapy, Los Angeles, California (Dr Dusing); Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India (Dr Krishna Rao).
Purpose: Investigate the effect of structured neonatal physical therapy program (SNP) on neurodevelopmental outcomes of moderate and late preterm (MLP) infants.
Methods: Sixty MLP infants were randomly allocated to usual care (UC) or SNP. A previous publication reported the effect of neonatal component of SNP at hospital discharge.
Medicine (Baltimore)
January 2025
Epilepsy Center, Children's Hospital Affiliated to Shandong University, Jinan, China.
Rationale: Developmental and epileptic encephalopathy (DEE) defines a group of severe and heterogeneous neurodevelopmental disorders. The voltage-gated potassium channel subfamily 2 voltage-gated potassium channel α subunit encoded by the KCNB1 gene is essential for neuronal excitability. Previous studies have shown that KCNB1 variants can cause DEE.
View Article and Find Full Text PDFHum Brain Mapp
January 2025
Center for MR Research, University Children's Hospital Zurich, Zurich, Switzerland.
The human brain connectome is characterized by the duality of highly modular structure and efficient integration, supporting information processing. Newborns with congenital heart disease (CHD), prematurity, or spina bifida aperta (SBA) constitute a population at risk for altered brain development and developmental delay (DD). We hypothesize that, independent of etiology, alterations of connectomic organization reflect neural circuitry impairments in cognitive DD.
View Article and Find Full Text PDFJ Family Med Prim Care
December 2024
Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
The Kabuki syndrome (KS) is a rare congenital disease that has two different types, KS1 and KS2, with variant in epigenetic gene KMT2D and KDM6A, respectively. It is associated with multiple abnormalities such as (developmental delay, atypical facial features, cardiac anomalies, minor skeleton anomalies, genitourinary anomalies, and mild to moderate intellectual disability). This syndrome can lead to neonatal hypoglycemia that results from hyperinsulinemia and electrolyte abnormalities.
View Article and Find Full Text PDFArch Public Health
January 2025
Community Medicine, ESIC Medical College & Hospital, K.K. Nagar, Chennai, 600078, India.
Background: In India, approximately 3.5 million children are affected by Developmental Delay (DD), often stemming from preterm births. These delays contribute to neurological and motor development delays, placing a significant financial burden on families.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!