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Dissociation of subjective and physiological stress responses in orexin deficient narcolepsy.
Sleep
January 2025
Center for Sleep Medicine, Sleep Research and Epileptology, Klinik Barmelweid AG, Barmelweid, Switzerland.
Longitudinal changes in brain activity during mnemonic discrimination over the course of Alzheimer’s disease.
Alzheimers Dement
December 2024
German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
Background: Mnemonic discrimination tasks (MDTs) hold potential for early detection of memory changes in Alzheimer’s disease (AD). Object and scene processing tasks differently tap into memory networks vulnerable to early tau and amyloid pathology, respectively. We used an object and scene MDT to assess longitudinal effects of AD on distinct functional memory networks and investigate their potential as markers for different disease stages.
View Article and Find Full Text PDFGeneral Anesthesia Occludes Ketamine's Antidepressant Response in a Rodent Model of Chronic Stress.
Psychedelic Med (New Rochelle)
December 2024
Departments of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Introduction: Psychedelic-induced experiences are thought to play an important role in the therapeutic actions of rapid-acting antidepressants. General anesthesia is one scenario in which patients can be rendered unconscious and masked to the psychedelic treatment, providing a simple yet effective method to examine drug-induced changes in the brain devoid of experiences.
Methods: Chronically stressed adult C57/BL6 male mice were given subhypnotic ketamine alone or ketamine and GABAergic anesthetic isoflurane at sedative (0.
Safety and cognitive pharmacodynamics following dose escalations with 3-methylmethcathinone (3-MMC): a first in human, designer drug study.
Neuropsychopharmacology
December 2024
Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands.
3-Methylmethcathinone (3-MMC) is a designer drug that belongs to the group of synthetic cathinones. The compound has been scheduled in many jurisdictions because of public health concerns associated with excessive use. To date, there are no clinical studies that have evaluated the risk profile of 3-MMC in the recreational range of low to moderate doses.
View Article and Find Full Text PDFBayesian Recursive and Structural Equation Models to Infer Causal Links Among Gait Visual Scores on Campolina Horses.
J Anim Breed Genet
December 2024
Animal Nutrition and Production Department, University of São Paulo, Pirassununga, São Paulo, Brazil.
Gait visual scores are widely applied to horse breeding because they are a fast and easy phenotyping strategy, allowing the numeric interpretation of a complex biological process such as gait quality. However, they may suffer from subjectivity or high environmental influence. We aimed to investigate potential causal relationships among six visual gait scores in Campolina horses.
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