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Pseudostellaria heterophylla (Miq.) Pax, a Traditional Folk Medicine, Ameliorates Colorectal Cancer by Remodeling the Tumor Immune Microenvironment.
J Ethnopharmacol
January 2025
Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:
Ethnopharmacological Relevance: Pseudostellaria heterophylla (Miq.) Pax (PH) is a traditional folk medicine, which is widely used clinically for digestive system tumors such as esophageal, gastric, colorectal, and liver cancers. The anti-tumor effect and mechanism of PH in colorectal cancer (CRC) deserves further study.
View Article and Find Full Text PDFA feedback loop between Paxillin and Yorkie sustains Drosophila intestinal homeostasis and regeneration.
Nat Commun
January 2025
The Department of Urology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200233, China.
Balanced self-renewal and differentiation of stem cells are crucial for maintaining tissue homeostasis, but the underlying mechanisms of this process remain poorly understood. Here, from an RNA interference (RNAi) screen in adult Drosophila intestinal stem cells (ISCs), we identify a factor, Pax, which is orthologous to mammalian PXN, coordinates the proliferation and differentiation of ISCs during both normal homeostasis and injury-induced midgut regeneration in Drosophila. Loss of Pax promotes ISC proliferation while suppressing its differentiation into absorptive enterocytes (ECs).
View Article and Find Full Text PDFPax inhibition: stressing proximal tubule for successful repair.
Am J Physiol Renal Physiol
February 2025
Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, United States.
Antioxidant, anti-prostate cancer potential, and phytochemical composition of the ethyl acetate stem bark extract of Boascia coriacea (Pax.).
PLoS One
December 2024
Department of Biochemistry, Microbiology and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, Nairobi, Kenya.
Background: The antioxidant and anticancer potential of natural compounds, particularly from medicinal plants, is increasingly being explored as alternatives to synthetic antioxidants and chemotherapeutics. Boascia coriacea (Pax) has been traditionally used for treating various ailments, including oxidative stress-related diseases and prostate cancer. However, there is a paucity of empirical evidence to validate the ethnomedicinal claims, hence this study.
View Article and Find Full Text PDFASAP1 and ARF1 regulate myogenic differentiation in rhabdomyosarcoma by modulating TAZ activity.
Mol Cancer Res
November 2024
National Cancer Institute, Frederick, MD, United States.
Article Synopsis
- Research indicates that despite existing therapies, the outlook for patients with refractory or recurrent rhabdomyosarcoma (RMS) remains poor, prompting exploration of differentiation-inducing treatments.
- In preclinical models of RAS-mutant PAX fusion-negative RMS, MEK1/2 inhibition has shown potential to encourage differentiation, slow tumor growth, and extend survival, although responses are often temporary.
- The study identifies ASAP1 and ARF1 as crucial regulators in promoting differentiation in FN-RMS cells, revealing that targeting these molecules may enhance treatment strategies by affecting key transcriptional regulators, such as WWTR1 (TAZ).
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