Purpose: This ex vivo study aimed to develop and evaluate a novel cylinder bioprosthetic valve for mitral and tricuspid valve replacements, addressing concerns related to valve size, anticoagulation, and postoperative morbidity.
Description: Existing bioprosthetic valves lack annulus-papillary muscle continuity. In contrast, our valve, which is crafted from autologous pericardium, maintains annulus-papillary muscle continuity, maximizes the orifice area when open, and closes in response to rising ventricular pressure, thus preserving mitral valve complexity. It also offers a comprehensive size range: implanted mitral valve diameters ranged from 13 to 26 mm, and implanted tricuspid valve diameters ranged from 15 to 28 mm.
Evaluation: Animal models demonstrated satisfactory coaptation lengths and excellent valve performance without regurgitation.
Conclusions: Our newly designed valve is a geometrically adaptable alternative to existing valves. Its autologous pericardium construction, open design position, and preservation of annulus-papillary muscle continuity address key limitations in existing implants. Moreover, with a broad size selection, this valve accommodates patients across all age groups. The innovative design and potential clinical benefits make this valve a breakthrough in atrioventricular valve replacement.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11708507 | PMC |
| http://dx.doi.org/10.1016/j.atssr.2023.08.005 | DOI Listing |
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