Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11708135 | PMC |
| http://dx.doi.org/10.1016/j.atssr.2023.03.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Survival outcomes in EIF2AK4 mutation-associated pulmonary arterial hypertension: seeking clarity in contrast.
Eur Heart J Case Rep
November 2024
National Pulmonary Hypertension Centre, Royal Brompton Hospital, Part of GSTT Foundation Trust, Sydney Street, London SW3 6NP, UK.
Article Synopsis
- Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary arterial hypertension (PAH) linked to mutations in the EIF2AK4 gene, particularly presenting severe outcomes for those with homozygous mutations.
- This case study highlights two patients with homozygous EIF2AK4 mutations who responded exceptionally well to pulmonary vasodilator therapy and showed stable health over a 2 to 10-year follow-up period.
- The findings suggest that intrapulmonary shunts (IPS) might help relieve pressure on the right ventricle while maintaining oxygen levels, indicating a potentially better prognosis for PVOD patients compared to classical PAH cases.
Retained Intrapulmonary Epicardial Pacing Wire Migrates Through Left Hilum.
Ann Thorac Surg Short Rep
June 2023
Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.
A Novel Surgical Method for Congenital Lung Malformations: A Pilot Study.
Semin Thorac Cardiovasc Surg
July 2022
Department of Pediatric Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu 610041, China.
Thoracoscopic surgery for congenital lung malformations (CLMs) has been widely used. However, there are still many shortcomings in the current surgical methods, such as the removal of some normal lung tissue and residual lesions. Thoracoscopic anatomical lesion resection (TALR) may be an effective and safe method to resolve these problems.
View Article and Find Full Text PDFSelective delipidation of Mycobacterium bovis BCG retains antitumor efficacy against non-muscle invasive bladder cancer.
Cancer Immunol Immunother
January 2023
Experimental Developmental Therapeutics (EDT) Program, Mays Cancer Center at UT Health MD Anderson, San Antonio, TX, USA.
Purpose: Repeated instillations of bacillus Calmette et Guérin (BCG) are the gold standard immunotherapeutic treatment for reducing recurrence for patients with high-grade papillary non-muscle invasive bladder cancer (NMIBC) and for eradicating bladder carcinoma-in situ. Unfortunately, some patients are unable to tolerate BCG due to treatment-associated toxicity and bladder removal is sometimes performed for BCG-intolerance. Prior studies suggest that selectively delipidated BCG (dBCG) improves tolerability of intrapulmonary delivery reducing tissue damage and increasing efficacy in preventing Mycobacterium tuberculosis infection in mice.
View Article and Find Full Text PDFUtilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle.
J Vis Exp
May 2022
Division of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School.
Smooth muscle cells (SMC) mediate the contraction of the airway and the intrapulmonary artery to modify airflow resistance and pulmonary circulation, respectively, hence playing a critical role in the homeostasis of the pulmonary system. Deregulation of SMC contractility contributes to several pulmonary diseases, including asthma and pulmonary hypertension. However, due to limited tissue access and a lack of culture systems to maintain in vivo SMC phenotypes, molecular mechanisms underlying the deregulated SMC contractility in these diseases remain fully identified.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!