, an Ascomycetes fungus, is the responsible pathogen for histoplasmosis. Although often asymptomatic, around 1% of cases progress to disseminated infection. Endovascular graft infections with this fungus have been reported, particularly on abdominal aortic or aortofemoral bypass grafts. Timely antifungal therapy followed by appropriate surgical intervention is vital for a favorable outcome to be achieved. We describe a case involving a 73-year-old man in whom disseminated histoplasmosis developed 2 decades after his ascending aortic aneurysm repair. He presented with a fungal ball in the proximal ascending portion of the aorta. The patient was successfully treated with an aortic root replacement and hemiarch reconstruction.
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http://dx.doi.org/10.1016/j.atssr.2023.11.028 | DOI Listing |
Med Mycol Case Rep
March 2025
Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
A 49-year old female, known to have had an asymptomatic pulmonary cavity since 2015, presented in 2023 with hemoptysis. Radiology showed a mass suspected to be an aspergilloma. Due to persistent hemoptysis, lobectomy was performed.
View Article and Find Full Text PDFAnn Thorac Surg Short Rep
June 2024
Department of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota.
, an Ascomycetes fungus, is the responsible pathogen for histoplasmosis. Although often asymptomatic, around 1% of cases progress to disseminated infection. Endovascular graft infections with this fungus have been reported, particularly on abdominal aortic or aortofemoral bypass grafts.
View Article and Find Full Text PDFPharmaceutics
November 2024
Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary.
This article reports on the scalability of a combined wet grinding technique applying planetary ball mill and ZrO pearls as the grinding medium. After the determination of the parameters in a laboratory scale, the tenfold scale-up method was set. Meloxicam (MEL) was used as a nonsteroidal anti-inflammatory drug (NSAID) intended for per os delivery.
View Article and Find Full Text PDFEMBO Rep
January 2025
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.
Pro-inflammatory macrophage activation is a hallmark example of how mitochondria serve as signaling organelles. Oxidative phosphorylation sharply decreases upon classical macrophage activation, as mitochondria are thought to shift from ATP production towards accumulating signals that amplify effector function. However, evidence is conflicting regarding whether this collapse in respiration is essential or dispensable.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080.
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