Background: Tricuspid anteroposterior patch (TRAPP) repair aims to address shortcomings of traditional annuloplasty in functional tricuspid regurgitation by selectively enlarging and translocating the anterior and posterior leaflets, but optimal patch width has not been identified.
Methods: An ex vivo model of the tricuspid valve was established in fresh porcine hearts by pneumatic pressurization of the ventricles. TRAPP repair was performed with patches of varying width (group 1, 1.0 cm; group 2, 1.5 cm; group 3, 2.0 cm). A 3-dimensional structured light scanner was used to image the topography of the tricuspid valve before and after TRAPP repair, and measurements were compared.
Results: Coaptation length increased with TRAPP repair in all groups (group 1, 44% [ = .004]; group 2, 70% [ < .001]; group 3, 82% [ = .002]). Coaptation increases in length and area were similar in groups 2 and 3, but the larger patch size of group 3 caused bulging above the annulus and significant changes in leaflet measurements.
Conclusions: Optimal patch size for TRAPP repair is 1.5 cm. This patch size maximally increased coaptation length but avoided abnormal systolic leaflet geometry (bulging) seen with the larger patch.
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http://dx.doi.org/10.1016/j.atssr.2023.12.002 | DOI Listing |
Ann Thorac Surg Short Rep
June 2024
Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Background: Tricuspid anteroposterior patch (TRAPP) repair aims to address shortcomings of traditional annuloplasty in functional tricuspid regurgitation by selectively enlarging and translocating the anterior and posterior leaflets, but optimal patch width has not been identified.
Methods: An ex vivo model of the tricuspid valve was established in fresh porcine hearts by pneumatic pressurization of the ventricles. TRAPP repair was performed with patches of varying width (group 1, 1.
Innovations (Phila)
December 2024
Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Objective: Annuloplasty is the most common strategy for repair of functional tricuspid regurgitation (FTR) but is not effective in patients with massive/torrential FTR or leaflet tethering. To address the deficits of tricuspid annuloplasty, TRicuspid Anterior and Posterior Patch (TRAPP) repair was developed, which is a pericardial patch augmentation of the anterior and posterior leaflets.
Methods: To test this repair, a previously validated ex vivo model in an explanted porcine heart was used, wherein annular and leaflet geometry were evaluated using a 3-dimensional structured light scanner at 4 time points: (1) baseline, (2) induction of FTR, (3) annuloplasty repair, and (4) patch repair.
Eur J Trauma Emerg Surg
October 2024
Institute for Biomechanics, BG Unfallklinik Murnau, Prof. Küntscher Str. 8, 82418, Murnau, Germany.
Purpose: In pertrochanteric femur fractures the risk for fracture healing complications increases with the complexity of the fracture. In addition to dynamization along the lag screw, successful fracture healing may also be facilitated by further dynamization along the shaft axis. The aim of this study was to investigate the mechanical stability of additional axial notch dynamization compared to the standard treatment in an unstable pertrochanteric femur fracture treated with cephalomedullary nailing.
View Article and Find Full Text PDFBrain
September 2024
Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Chronic active lesions (CAL) are an important manifestation of chronic inflammation in multiple sclerosis and have implications for non-relapsing biological progression. In recent years, the discovery of innovative MRI and PET-derived biomarkers has made it possible to detect CAL, and to some extent quantify them, in the brain of persons with multiple sclerosis, in vivo. Paramagnetic rim lesions on susceptibility-sensitive MRI sequences, MRI-defined slowly expanding lesions on T1-weighted and T2-weighted scans, and 18-kDa translocator protein-positive lesions on PET are promising candidate biomarkers of CAL.
View Article and Find Full Text PDFBrain
May 2024
Institute for Myelin and Glia Exploration, Departments of Biochemistry and Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
Multiple sclerosis is a chronic inflammatory disease in which disability results from the disruption of myelin and axons. During the initial stages of the disease, injured myelin is replaced by mature myelinating oligodendrocytes that differentiate from oligodendrocyte precursor cells. However, myelin repair fails in secondary and chronic progressive stages of the disease and with ageing, as the environment becomes progressively more hostile.
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