This study explores the deoxygenation of pyridine -oxides and presents a one-step photoredox method for the direct synthesis of 2-hydroxymethylated pyridines from pyridine -oxides. Mechanism studies elucidate the role of the catalyst and provide evidence of the possible electron transfer process and the formation of key radicals. A range of pyridine derivatives, particularly 2-hydroxymethyl-substituted pyridines, which may be difficult to obtain, can be synthesized in a single step.
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| http://dx.doi.org/10.1021/acs.joc.4c02770 | DOI Listing |
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