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Spectroscopic liquid biopsy: A novel promising method for early cancer screening.
J Transl Med
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State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, 211189, Nanjing, China.
No Bridge between Us: EXAFS and Computations Confirm Two Distant Iron Ions Comprise the Active Site of Alkane Monooxygenase (AlkB).
J Am Chem Soc
January 2025
Department of Chemistry, Barnard College, 3009 Broadway, New York, New York 10027, United States.
Alkane monooxygenase (AlkB) is the dominant enzyme that catalyzes the oxidation of liquid alkanes in the environment. Two recent structural models derived from cryo-electron microscopy (cryo-EM) reveal an unusual active site: a histidine-rich center that binds two iron ions without a bridging ligand. To ensure that potential photoreduction and radiation damage are not responsible for the absence of a bridging ligand in the cryo-EM structures, spectroscopic methods are needed.
View Article and Find Full Text PDFHost-Guest Complexation of Olmesartan Medoxomil by Heptakis(2,6-di-O-methyl)-β-cyclodextrin: Compatibility Study with Excipients.
Pharmaceutics
December 2024
Faculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
Olmesartan medoxomil (OLM) is the prodrug of olmesartan, an angiotensin II type 1 receptor blocker that has antihypertensive and antioxidant activities and renal protective properties. It exhibits low water solubility, which leads to poor bioavailability and limits its clinical potential. To improve the solubility of OLM, a host-guest inclusion complex (IC) between heptakis(2,6-di-O-methyl)-β-cyclodextrin (DMβCD) and the drug substance was obtained.
View Article and Find Full Text PDFSynthesis and Characterization of Photocurable Difunctional Monomers for Medical Applications.
Polymers (Basel)
December 2024
Department of Polymer and Biomaterials Science, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Al. Piastów 45, 70-311 Szczecin, Poland.
Photocurable materials offer a rapid transition from a liquid to a solid state, and have recently received great interest in the medical field. However, while dental resins are very popular, only a few materials have been developed for soft tissue repair. This study aims to synthesize a difunctional methacrylate monomer using a dibutyltin dilaurate which is suitable for the photocuring of soft materials.
View Article and Find Full Text PDFVisible Light Spectroscopy of Liquid Solutes from Femto- to Attoliter Volumes Inside a Single Nanofluidic Channel.
ACS Nano
January 2025
Department of Physics, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.
UV-vis spectroscopy is a workhorse in analytical chemistry that finds application in life science, organic synthesis, and energy technologies like photocatalysis. In its traditional implementation with cuvettes, it requires sample volumes in the milliliter range. Here, we show how nanofluidic scattering spectroscopy (NSS), which measures visible light scattered from a single nanochannel in a spectrally resolved way, can reduce this sample volume to the attoliter range for solute concentrations in the mM regime, which corresponds to as few as 10 probed molecules.
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