Background: The identification of the key factors that affect academic success in nursing students, including health-related quality of life, academic burnout, and academic motivation, has been of the utmost importance to date. In this context, the present study sought to examine the relationship between health-related quality of life and academic success, with academic burnout and academic motivation mediating that relationship.

Methods: This analytical cross-sectional study included 262 eligible nursing students selected through convenience sampling from the School of Nursing and Midwifery at Shahid Beheshti University of Medical Sciences, Tehran, Iran. To evaluate health-related quality of life, academic burnout, and academic motivation, the 12-item Short Form Health Survey, the Academic Motivation Scale, and Breso's Academic Burnout Scale were administered, respectively. The study achieved a 95% response rate. Academic success was assessed using the nursing program grade point average. Data analysis was conducted using SPSS Statistics (version 26) and Mplus (version 6.12) software, with a significance level set at 0.05.

Results: The findings of the study indicated that although health-related quality of life did not directly affect academic success, it could potentially enhance academic success through the mediation of intrinsic motivation (B = 0.005, 95% CI = -0.01 to 0.005, p ≤ 0.05). Furthermore, health-related quality of life can increase academic success through the mediation of academic burnout and intrinsic motivation (B = 0.013, 95% CI = 0.005 to 0.02, p ≤ 0.01). This indicates that academic burnout and intrinsic motivation significantly mediate the path from the health-related quality of life to academic success.

Conclusions: The study findings indicate that nursing education planners and instructors should develop and implement appropriate measures to enhance academic success in nursing students. These measures should also promote their health-related quality of life, academic motivation, and reduce academic burnout.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720755PMC
http://dx.doi.org/10.1186/s12909-025-06661-6DOI Listing

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