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World Psychiatry Exchange Program 2.0: Enhancing Collaborations Between Early Career Psychiatrists.
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Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.
Biomarkers.
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Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands.
Background: Tau-PET imaging allows in-vivo detection of neurofibrillary tangles. One tau-PET tracer (i.e.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
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Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands.
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View Article and Find Full Text PDFBidirectional histone monoaminylation dynamics regulate neural rhythmicity.
Nature
January 2025
Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Histone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression. We previously demonstrated that serotonylation and dopaminylation of Gln5 of histone H3 (H3Q5ser and H3Q5dop, respectively) are catalysed by transglutaminase 2 (TG2), and alter both local and global chromatin states. Here we found that TG2 additionally functions as an eraser and exchanger of H3 monoaminylations, including H3Q5 histaminylation (H3Q5his), which displays diurnally rhythmic expression in brain and contributes to circadian gene expression and behaviour.
View Article and Find Full Text PDFOccasioned by the publication of , the text represents exchanges held in the summer of 2024 at the invitation of . It addresses the genesis and the history of the project, and its impact on psychoanalytic rethinking, formation, and practice. While exploring the potential and the limits of revisioning, it also raises questions about the nature of transmission of psychoanalytic knowledge and about the field's relation to the state of its own standards in the age of Anthropocene.
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