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Dereplication of Natural Product Antifungals via Liquid Chromatography-Tandem Mass Spectrometry and Chemical Genomics.
Molecules
December 2024
Pharmaceutical Sciences Division, University of Wisconsin-Madison, Madison, WI 53705, USA.
Recently expanded reports of multidrug-resistant fungal infections underscore the need to develop new and more efficient methods for antifungal drug discovery. A ubiquitous problem in natural product drug discovery campaigns is the rediscovery of known compounds or their relatives; accordingly, we have integrated Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for structural dereplication and Yeast Chemical Genomics for bioprocess evaluation into a screening platform to identify such compounds early in the screening process. We identified 450 fractions inhibiting and the resistant strains of and among more than 40,000 natural product fractions.
View Article and Find Full Text PDFMetabolomics and dereplication strategies for the study of bioactive metabolites derived from plants and fungi.
Fitoterapia
January 2025
Institute of Chemistry, Federal University of Alfenas (UNIFAL-MG), 37130-001 Alfenas, Minas Gerais, Brazil. Electronic address:
Metabolomics to target insecticidal compounds of var. against (J. E. Smith) (Lepidoptera: Noctuidae).
Nat Prod Res
December 2024
Laboratório de Fitoquímica, Química Medicinal e Metabolômica - LFQMM - Instituto de Química - Universidade Federal de Alfenas - UNIFAL, Alfenas, MG, Brazil.
The fall armyworm is the most prevalent plague in crops associated with a reduction in corn production by up to 34%. Pesticides have been used to reduce this plague, but they cause several environmental problems including resistance, ecological imbalance, and toxicity to the final consumer. The use of plant extracts has been an effective manner of eradicating this plague from crop plantations.
View Article and Find Full Text PDFActinomycetota From Macroalgae as Rich Source for Natural Products Discovery Revealed Through Culture-Dependent and -Independent Approaches.
Microb Biotechnol
December 2024
CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Matosinhos, Portugal.
Actinomycetota are unrivalled producers of bioactive natural products, with strains living in association with macroalgae representing a prolific-yet largely unexplored-source of specialised chemicals. In this work, we have investigated the bioactive potential of Actinomycetota from macroalgae through culture-dependent and -independent approaches. A bioprospecting pipeline was applied to a collection of 380 actinobacterial strains, recovered from two macroalgae species collected in the Portuguese northern shore-Codium tomentosum and Chondrus crispus-in order to explore their ability to produce antibacterial, antifungal, anticancer and lipid-reducing compounds.
View Article and Find Full Text PDFImproved Skin Barrier Function Along with Hydration Benefits of Extract, Aesculin, and Schaftoside and LC-HRMS/MS Dereplication of Its Bio-Active Components.
Int J Mol Sci
November 2024
L'Oréal Research and Innovation, Bangalore 560067, India.
The skin hydration level is a key factor that influences the physical and mechanical properties of the skin. The stratum corneum (SC), the outermost layer of the epidermis, is responsible for the skin's barrier function. In this study, we investigated the role of a unique composition of extract for its ability to activate CD44, a cell-surface receptor of hyaluronic acid, and aquaporin-3, a water-transporting protein, in human keratinocytes (HaCaT).
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