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Prolidase deficiency, a rare inborn error of immunity, clinical phenotypes, immunological features, and proposed treatments in twins.
Allergy Asthma Clin Immunol
February 2022
Division of Immunology, Department of Paediatrics, Dalhousie University, IWK Health Centre, Halifax, Canada.
Background: Prolidase deficiency (PD) is an autosomal recessive inborn multisystemic disease caused by mutations in the PEPD gene encoding the enzyme prolidase D, leading to defects in turnover of proline-containing proteins, such as collagen. PD is categorized as a metabolic disease, but also as an inborn error of immunity. PD presents with a range of findings including dysmorphic features, intellectual disabilities, recurrent infections, intractable skin ulceration, autoimmunity, and splenomegaly.
View Article and Find Full Text PDFRole of prolidase activity and oxidative stress biomarkers in unexplained infertility.
Int J Gynaecol Obstet
March 2022
Department of Endocrinology and Metabolism, School of Medicine, Gaziantep University, Gaziantep, Turkey.
Objective: Our aim was to explore the significance of serum prolidase enzyme activity and oxidative stress in women with unexplained infertility (UEI).
Methods: In this case-control study (n = 160; 86 cases; 74 controls) prolidase enzyme activity and total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and vitamin E were measured in plasma using enzyme-linked immunosorbent assays.
Results: Prolidase enzyme activity and TAS levels were particularly higher in the patient group (P = 0.
Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase.
Int J Mol Sci
January 2021
Department of Analysis and Bioanalysis of Medicines, Medical University of Bialystok, Kilińskiego 1, 15-089 Bialystok, Poland.
Although the role of platelet-rich plasma (PRP) in tissue regeneration has been confirmed in many studies, the mechanism of this process is still not fully understood. Human keratinocytes (HaCaT) cells were used as an experimental model for studies on the effects of PRP on cell proliferation, migration, collagen biosynthesis, prolidase activity, and its expression and anabolic signaling. The activation of epidermal growth factor receptor (EGFR), β-integrin, and insulin-like growth factor-1 receptor (IGF-1R) by PRP were investigated by western blot and immunocytochemistry.
View Article and Find Full Text PDFPlasma prolidase levels are high in schizophrenia but not in first-episode psychosis.
Int Clin Psychopharmacol
January 2021
Department of Psychiatry, Gulhane Medical Faculty.
An increasing number of studies have focussed on the neurobiology of schizophrenia (SCH), contributing to a better understanding of this disorder. Prolidase is a metalloprotease found in various tissues, which has been associated with the concentrations of proline, a neurotransmitter, in the brain. There is evidence to suggest that elevated proline levels play a role in SCH.
View Article and Find Full Text PDFZiziphus jujube ameliorated cavernosal oxidative stress and fibrotic processes in cavernous nerve injury-induced erectile dysfunction in a rat model.
Andrologia
August 2020
Department of Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey.
The aim of this study was to investigate potential antioxidant and antifibrotic effects of Ziziphus jujube (ZJ) in a cavernosal nerve injury (CNI)-induced erectile dysfunction (ED) rat model. Forty-eight male rats were assigned to six-sized groups as group 1: sham-operated; group 2: sham-operated + low-dose ZJ (200 mg/kg); group 3: sham-operated + high-dose ZJ (400 mg/kg); group 4: CNI + distilled water; group 5: CNI + low-dose ZJ; and group 6: CNI + high-dose ZJ. At the end of 2 weeks, intracardiac blood was taken and rats were sacrificed.
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