We talk to Xiaoyue Wang and Jinhua Leng, corresponding authors of "Single-cell and spatial transcriptomic profiling revealed niche interactions sustaining growth of endometriotic lesions" in this issue of Cell Genomics, about their research, the key implications of their study, and their advice for other scientists.
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Declining precipitation frequency may drive earlier leaf senescence by intensifying drought stress and enhancing drought acclimation.
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January 2025
The Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, 100101, Beijing, China.
Precipitation is an important factor influencing the date of foliar senescence, which in turn affects carbon uptake of terrestrial ecosystems. However, the temporal patterns of precipitation frequency and its impact on foliar senescence date remain largely unknown. Using both long-term carbon flux data and satellite observations across the Northern Hemisphere, we show that, after excluding impacts from of temperature, radiation and total precipitation by partial correlation analysis, declining precipitation frequency may drive earlier foliar senescence date from 1982 to 2022.
View Article and Find Full Text PDFMAPK pathway activating alteration and immunotherapy efficacy in squamous cell lung carcinoma: results from the randomized, prospective SQUINT trial.
Clin Cancer Res
January 2025
Istituti Fisioterapici Ospitalieri, Italy.
Background: The role of activating alterations in the MAPK pathway in predicting immunotherapy efficacy in lung squamous cell carcinoma (LSCC) patients is largely unknown. The aims of the randomized, phase II SQUINT trial were to assess the efficacy of nivolumab plus ipilimumab (NI) versus platinum-based chemotherapy plus nivolumab (N-CT) and to identify clinically available biomarkers of response to immunotherapy in patients with advanced or metastatic LSCC.
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Midwives perspectives of barriers and facilitators for the practice of promoting women's positive childbirth experience in China: A qualitative study.
Women Birth
January 2025
School of Nursing, Anhui Medical University, No.81 Meishan Road, Shushan District, Hefei City, Anhui Province 230032, PR China. Electronic address:
Background: Women-centered care for positive childbirth experiences is currently a global trend. However, there are some barriers to promoting women's positive childbirth experiences in practice. This study explored midwives' perspectives on the barriers and facilitators to promoting women's positive childbirth experience in practice.
View Article and Find Full Text PDFSingle-cell and spatial transcriptomic profiling revealed niche interactions sustaining growth of endometriotic lesions.
Cell Genom
January 2025
National Clinical Research Center for Obstetric & Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. Electronic address:
Endometriosis is a chronic condition with limited therapeutic options. The molecular aberrations promoting ectopic attachment and interactions with the local microenvironment sustaining lesion growth have been unclear, prohibiting development of targeted therapies. Here, we performed single-cell and spatial transcriptomic profiling of ectopic lesions and eutopic endometrium in endometriosis.
View Article and Find Full Text PDFWe talk to Xiaoyue Wang and Jinhua Leng, corresponding authors of "Single-cell and spatial transcriptomic profiling revealed niche interactions sustaining growth of endometriotic lesions" in this issue of Cell Genomics, about their research, the key implications of their study, and their advice for other scientists.
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