In this issue of Cell Host & Microbe, Wu et al. identified enriched gut Aspergillus tubingensis in patients with polycystic ovary syndrome (PCOS). In mice, this fungus induced a PCOS-like phenotype by inhibiting interleukin (IL)-22 secretion from ILC3s via the AT-C1-AhR axis. PCOS, a women's health concern, is influenced by the gut mycobiome.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.chom.2024.12.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fungal influence: The role of the gut mycobiome in women's health.
Cell Host Microbe
January 2025
State Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:
In this issue of Cell Host & Microbe, Wu et al. identified enriched gut Aspergillus tubingensis in patients with polycystic ovary syndrome (PCOS). In mice, this fungus induced a PCOS-like phenotype by inhibiting interleukin (IL)-22 secretion from ILC3s via the AT-C1-AhR axis.
View Article and Find Full Text PDFA Meta-Analysis of the Human Gut Mycobiome Using Internal Transcribed Spacer Data.
Microorganisms
December 2024
School of Engineering Medicine, Beihang University, Rd37, Xueyuan, Haidian, Beijing 100191, China.
The intestinal mycobiome is closely related to human health. There have been several reports investigating the association between the gut fungi and disease, but there is still a lack of overall assessment of the human gut mycobiome. Here, we performed a meta-analysis based on 2372 ITS (Internal Transcribed Spacer) data collected publicly online.
View Article and Find Full Text PDFExploring Protein Functions of Gut Bacteriome and Mycobiome in Thai Infants Associated with Atopic Dermatitis Through Metaproteomic and Host Interaction Analysis.
Int J Mol Sci
December 2024
Department of Zoology, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
Atopic dermatitis (AD), a prevalent allergic skin condition in children, has been closely associated with imbalances in the gut microbiome. To investigate these microbial alterations and their functional implications, we investigated protein expression, functions and interactions of the gut bacteriome and mycobiome as well as the human proteome in Thai infants with AD using integrative metaproteomic and host interaction analysis. As we observed, probiotic species, such as and , were reduced in abundance in the AD group while key pathogenic bacteria and fungi, such as and , increased in abundance.
View Article and Find Full Text PDFDiverse Colonisation and Disease Associations of the Human Commensal Malassezia: Our Body's Secret Tenant.
Mycoses
January 2025
Cell Biology and Molecular Genetics, Yenepoya Research Centre, Yenepoya (Deemed to Be University), Mangalore, India.
A niche in the context of microorganisms defines the specific ecological role or habitat inhabited by microbial species within an ecosystem. For the human commensal Malassezia, the skin surface is considered its primary niche, where it adapts to the skin environment by utilising lipids as its main carbon and energy source. However pathogenic characteristics of Malassezia include the production of allergens, immune modulation and excessive lipid utilisation, which result in several diseases such as pityriasis versicolor, seborrheic dermatitis, Malassezia folliculitis and atopic dermatitis.
View Article and Find Full Text PDFThe fungal gut microbiota in pediatric-onset multiple sclerosis.
Front Microbiol
December 2024
Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Evidence suggests that the gut microbiome may play a role in multiple sclerosis (MS). However, the majority of the studies have focused on gut bacterial communities; none have examined the fungal microbiota (mycobiota) in persons with pediatric-onset multiple sclerosis (POMS). We examined the gut mycobiota in persons with and without POMS through a cross-sectional examination of the gut mycobiota from 46 participants' stool samples (three groups: 18 POMS, 13 acquired monophasic demyelinating syndromes [monoADS], and 15 unaffected controls).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!