Background: Trans girls may initiate early puberty blockers once puberty has started in order to prevent the development of masculine secondary sexual characteristics. Depending on how early the puberty blockers are administered, voice may have reached a certain degree of development and have acquired typically male acoustic and phonetic parameters, which can cause discomfort and affect the adolescent's quality of life.
Purpose: The aim of the present study was to (1) determine if there are differences in discomfort with the self-perceiver voice according to the moment of puberty block (PB), and (2) find a relation between vocal discomfort and variables such a voice phonetic/acoustic characteristics and self-perception of voice.
Method: A cross-sectional study was carried out. Differences in vocal discomfort between a group of trans girls with early puberty block and a group with late puberty block were compared. The participants were given the Voice Handicap index (VHI-30) and the Trans Women Voice Questionnaire (TWVQ) to assess vocal discomfort. In the same way, their anthropometric, clinical and vocal data, such as FO, were collected. The Kruskal-Wallis test was used to compare the differences in the TWVQ punctuation according to the Tanner stage.
Results: The value of the fundamental frequency (FO) was 71.5 Hz higher in the early puberty block group (p < 0.001). The total scores of the questionnaires are higher in the late puberty block group (37.5 points in the TWVQ and 26 points in the VHI-30, p < 0.001 in both cases) Vocal self-perception tends to be more feminine in users with early blocked puberty (p = 0.001). There is a negative correlation between FO and puberty block age (r = 0.669) as well as with the TWVQ score (r = 0.755).
Conclusion: Early puberty blockers seem to be related to lower score in TWVQ and VHI-30. It could represent less vocal discomfort in trans girls. Acute voice seem to be more frequent in early puberty blocked because Fundamental frequency are significantly higher.
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http://dx.doi.org/10.1016/j.earlhumdev.2024.106190 | DOI Listing |
Animal Model Exp Med
January 2025
Guangdong Medical Laboratory Animal Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Background: Makorin ring finger protein 3 gene (MKRN3) gene mutation is the most common genetic cause of central precocious puberty (CPP) in children. Due to the lack of ideal MKRN3-modified animal model (MKRN3-modified mice enter puberty only 4-5 days earlier than normal mice), the related research is limited.
Methods: Therefore, the MKRN3-modified rabbit was developed using CRISPR (clustered regularly interspaced short palindromic repeats) gene editing technology.
Toxins (Basel)
December 2024
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
This study aims to examine the hazards of zearalenone (ZEN) to humans and assess the risk of dietary exposure to ZEN, particularly in relation to precocious puberty in children from the Zhejiang Province. The test results from five types of food from the Zhejiang Province show that corn oil has the highest detection rate of 87.82%.
View Article and Find Full Text PDFJ Pediatr Endocrinol Metab
January 2025
Department of Paediatrics, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Objectives: Kisspeptin plays a major role in the onset of puberty by stimulating the gonadotropin-releasing hormone (GnRH) neurons. The aim of this study was to investigate whether GnRH inhibits kisspeptin secretion via a negative feedback mechanism and potential associations between kisspeptin levels and other hormones of importance for pubertal onset.
Methods: Thirteen girls with suspected central precocious puberty underwent a GnRH stimulation test twice in a randomized, placebo-controlled manner.
Scand J Clin Lab Invest
January 2025
Department of Medical Biochemistry, Ministry of Health, Ankara Bilkent City Hospital, Ankara, Turkey.
Analytical errors related to endogenous or exogenous substances are a cause of unnecessary investigation, intervention, and patient concern especially in immunoassay platforms. In this report, we systematically screened for estradiol interference using a practical algorithm. For extended research in interference screening, repeated estradiol measurements for control and case samples were carried out for method comparison (three immunoassay platforms and one liquid chromatography-mass spectrometry (LC-MS/MS) measurement), dilution test, polyethylene glycol (PEG) precipitation, and heterophile antibody blocking tube.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Diabetes and Endocrinology, Children's Health Ireland at Crumlin, Dublin 12, Ireland.
A boy in mid-childhood presented with right-sided gynaecomastia, which was excised. He represented and, on review by endocrinology, Tanner staging showed stage 2 left-sided glandular breast tissue and some features of virilisation. His testicular volumes remained prepubertal (3 mL).
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