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CORR Insights®: Do Patients of Different Levels of Affluence Receive Different Care for Pediatric Osteosarcomas? One Institution's Experience.
Clin Orthop Relat Res
December 2024
Chief of the Orthopaedic Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
CORR Insights®: What Factors Are Associated With Implant Revision in the Treatment of Pathologic Subtrochanteric Femur Fractures?
Clin Orthop Relat Res
December 2024
Orthopedic Surgeon, Department of Orthopedic Surgery and Sports Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
CORR Insights®: Is the Use of a Buprenorphine Transdermal Patch More Effective Than Oral Medications for Postoperative Analgesia After Arthroscopic Rotator Cuff Repair? A Randomized Clinical Trial.
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Physician, Peachtree Orthopaedic Clinic, Atlanta, GA, USA.
Biomarkers.
Alzheimers Dement
December 2024
University of California, Los Angeles Integrative Biology and Physiology (IBP), Los Angeles, CA, USA.
Background: APOE is in linkage disequilibrium with the length of poly-T repeats at the rs10524523 ('523) locus of the TOMM40 gene. APOE-ε3 is associated with short (S) and (VL) variants of '523 in white and Black individuals. In white individuals, APOE-ε4 is associated with the long (L) '523 variant, but is associated with '523-S, '523-L, and '523-VL variants in Black individuals.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is a neurodegenerative disorder characterised by cognitive decline and progressive deterioration of brain function. Recent research has suggested a complex interplay between AD and bone health, with individuals affected by AD exhibiting an increased propensity for fractures and falls. Our preclinical studies in PSEN, MAPT P301 S and FDD mice have shown sex-dependent changes in the bone in AD mice, compared to their age-matched wild type mice.
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