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Complications of the Bacillus Calmette-Guerin vaccine as an early warning sign of inborn errors of immunity: a report of 197 patients.
Front Immunol
December 2024
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Background: According to the WHO's recommendation for developing countries, Bacillus Calmette-Guerin (BCG) vaccination has been implemented in some countries as part of national vaccination programs at birth. Although it is generally considered safe, some complications may occur; including BCGitis (local) or BCGosis (systemic), ranging from mild like local abscesses to fatal impediments like osteomyelitis and disseminated BCG infection. This study aimed to determine the spectrum of inborn errors of immunity (IEI) in BCG-vaccinated neonates experiencing local or systemic complications.
View Article and Find Full Text PDFNeonatal Necrotizing Fasciitis of the Foot Caused by Bacillus cereus: A Case Report.
Cureus
November 2024
Division of Orthopaedic Surgery, Tokyo Women's Medical University, Tokyo, JPN.
Few neonatal cases of soft tissue and osteoarticular infections with have been reported. We report a rare clinical presentation of necrotizing fasciitis of the foot caused by in a 17-day-old male neonate with hypoplastic left-sided heart syndrome. Fulminant progressive black skin necrosis was triggered by fresh frozen plasma leakage from the peripheral venous access.
View Article and Find Full Text PDFNeonatal Chronic Granulomatous Disease With Septic Arthritis and Osteomyelitis: Diagnostic and Therapeutic Challenge With Literature Review.
J Investig Med High Impact Case Rep
December 2024
College of Medicine, University of Baghdad, Baghdad, Iraq.
This case report underlines the diagnostic and therapeutic dilemmas in a 19-day-old neonate who had presented with features suggestive of chronic granulomatous disease (CGD). The baby had a history of fever, lethargy, and masses on the skin, for which an extensive diagnostic workup was needed to rule out infective etiology given no improvement with initial empiric therapy. Laboratory investigations, including imaging and genetic studies, confirmed the diagnosis of CGD.
View Article and Find Full Text PDFIdentifying opportunities to reduce imaging overuse in hospitalized children.
J Hosp Med
December 2024
Division of Hospital Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Article Synopsis
- Radiologic imaging is often used in children's hospitals to assist with diagnoses, but variations in how it's performed can lead to unnecessary costs and risks.
- A study analyzed inpatient pediatric conditions across 50 hospitals from 2017 to 2019, focusing on those with high imaging prevalence and costs, and found that conditions like pectus excavatum and scoliosis had the highest imaging rates.
- The findings indicated significant variations in imaging-related costs among hospitals, highlighting the need for improved guidelines to reduce overuse and improve care in pediatric imaging.
Investigating Osteomyelitis as a Rare Adverse Effect of Vaccination in the Pediatric Population.
Pathogens
November 2024
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G D'Alessandro", University of Palermo, 90127 Palermo, Italy.
Immunization is a preventive measure of crucial importance. As with any other medication, side effects are a possibility and include the rare occurrence of severe infections, such as osteomyelitis. We report an unusual case of pediatric osteomyelitis following vaccination and provide a review of similar reports submitted to the Vaccine Adverse Event Report System (VAERS), aiming to explore the association between the vaccination procedure and the occurrence of osteomyelitis in childhood.
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