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Should we add McKenzie exercises to current guidelines for the treatment of (sub)acute non-specific low back pain? A Cochrane Review summary with commentary.
Am J Phys Med Rehabil
December 2024
IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial.
Lancet
June 2024
MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK. Electronic address:
Article Synopsis
- The study investigates the effectiveness and optimal duration of androgen deprivation therapy (ADT) combined with postoperative radiotherapy for patients with localized prostate cancer following radical prostatectomy.
- A randomised controlled trial, RADICALS-HD, compared short-course ADT (6 months) to long-course ADT (24 months) among participants who met specific criteria, including PSA levels and absence of metastatic disease.
- The primary outcome measured was metastasis-free survival, with the trial aiming to determine if longer ADT duration leads to better survival rates, involving over 1,500 patients from 2008 to 2015.
Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial.
BMJ Open
April 2024
Department of Anaesthesia, Critical Care and Pain Medicine, University of Edinburgh Division of Clinical and Surgical Sciences, Edinburgh, UK
Introduction: An association between deep sedation and adverse short-term outcomes has been demonstrated although this evidence has been inconsistent. The A2B (alpha-2 agonists for sedation in critical care) sedation trial is designed to determine whether the alpha-2 agonists clonidine and dexmedetomidine, compared with usual care, are clinically and cost-effective. The A2B intervention is a complex intervention conducted in 39 intensive care units (ICUs) in the UK.
View Article and Find Full Text PDFMr. Toad's Wild Fungi: Fungal Isolate Diversity on Colorado Boreal Toads and their Capacity for Pathogen Inhibition.
Fungal Ecol
December 2023
University of Colorado Boulder, Department of Ecology and Evolutionary Biology.
The amphibian skin pathogen () has caused an ongoing biodiversity crisis, including in the locally endangered Colorado boreal toad (). Although researchers have investigated the bacteria living on amphibian skin and how they interact with , there is less information about fungal community members. This study describes (1) the diversity of culturable fungi from boreal toad skin, (2) which subset of these isolates is -inhibitory, and (3) how affects these isolates' growth and morphology.
View Article and Find Full Text PDFEffectiveness of Physiotherapy Exercises on Pain, Range of Motion, and Quality of Life in Patients With Ankylosing Spondylitis: A Case Report.
Cureus
January 2024
Department of Musculoskeletal Physiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Ankylosing spondylitis (AS) is an inflammatory disease that affects the entire body. Immune cells positive for human leukocyte antigen B27 are thought to be involved in the pathophysiology. AS is caused by inflammation of the spinal joints, leading to stiffness and reduced spinal movement.
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