The mechanistic understanding of how alkylamines impact Ni-metallophotoredox C-N coupling to form diarylamines remains unclear. In this study, 12-alkylamines were evaluated as additives to determine their effects on the synthesis of diarylamines in a flow photochemical system. Notably, -hexylamine demonstrated the most significant promotional effect. Spectroscopic studies and experimental data reveal -hexylamine substitutes DABCO as a Ni catalyst ligand, enhancing yields particularly in sterically hindered arylamines.
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| http://dx.doi.org/10.1021/acs.joc.4c02106 | DOI Listing |
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