Background: Dementia is a major public health problem affecting millions of people worldwide. Early diagnosis and intervention are essential to improve quality of life and reduce the burden of dementia. Recently, voice digital biomarkers have emerged as a promising approach for the early detection of dementia owing to its clinical utility and accessibility.
Method: In this study, we present a voice biomarker‐based dementia prediction system using a Korean dataset from the AI hub entitled cognitive disorder diagnostic speech/dialogue. A total of 5,769 voice recordings were obtained, of which 2,424 were from CN, 1,611 from MCI, and 1,734 from AD, and were recorded during the administration of cognitive tests. We first extracted dementia‐related speech biomarkers using signal processing and speech activity detection. The extracted speech biomarkers were then used to predict the Clinical Dementia Rating (CDR) to discriminate the severity of dementia from the dataset using ML/DL framework. We also developed an automated engine to extract the voice biomarkers and predict the CDR. The engine was deployed using Docker containers and a web service was implemented using the Flutter framework.
Result: The results showed that the proposed system achieved a CDR prediction accuracy of 83.6% and precision of 0.872. This is comparable to the accuracy of other voice biomarker‐based dementia prediction systems developed using Western datasets. A Flutter‐based web service is shown in the attached figure.
Conclusion: The proposed system is a promising new approach for early detection of dementia. It is easy to use, accessible and inexpensive, making it a potential tool for widespread use. The system could be used to screen large numbers of people for dementia, potentially leading to earlier diagnosis and intervention. In addition, the use of a low‐language digital voice biomarker makes the system more accessible to people from different linguistic backgrounds. This could help to reduce inequalities in dementia detection and care. In the future, we plan to add a variety of predictive models, including depression and Parkinson's disease. More detailed information, including a published web site, will be released through the AAIC 2024 poster session.
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http://dx.doi.org/10.1002/alz.088519 | DOI Listing |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11716498 | PMC |
J Neurosurg
January 2025
4Department of Neurosurgery, Korea University Anam Hospital, Seoul, Republic of Korea.
Objective: Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is safe and potentially beneficial in patients with Alzheimer's disease (AD) for the removal of amyloid-beta (Aβ) plaques. However, the optimal BBB opening intervals and number of treatment sessions for clinical improvement remain undefined. Therefore, the aim of this study was to evaluate the safety and benefits of repeated and more extensive BBB opening alone.
View Article and Find Full Text PDFCrit Care Med
November 2024
Department of Intensive Care, Copenhagen University Hospital, Copenhagen, Denmark.
Objectives: Rocking motion therapy has been shown to calm people with dementia but has never been investigated in delirious patients in the ICU. The aim of this clinical trial was to investigate the efficacy and safety of a rocking motion vs. nonrocking motion chair on the duration of delirium and intensity of agitation in ICU patients with delirium.
View Article and Find Full Text PDFCrit Care Med
January 2025
Department of Intensive Care, Copenhagen University Hospital, Copenhagen, Denmark.
Objectives: Rocking motion therapy has been shown to calm people with dementia but has never been investigated in delirious patients in the ICU. The aim of this clinical trial was to investigate the efficacy and safety of a rocking motion vs. nonrocking motion chair on the duration of delirium and intensity of agitation in ICU patients with delirium.
View Article and Find Full Text PDFCrit Care Med
December 2024
Department of Psychiatry and Human Behavior, Brown University, Alpert Medical School, Providence, RI.
Objectives: Neurocritically ill patients are at high risk for developing delirium, which can worsen the long-term outcomes of this vulnerable population. However, existing delirium assessment tools do not account for neurologic deficits that often interfere with conventional testing and are therefore unreliable in neurocritically ill patients. We aimed to determine the accuracy and predictive validity of the Fluctuating Mental Status Evaluation (FMSE), a novel delirium screening tool developed specifically for neurocritically ill patients.
View Article and Find Full Text PDFAm J Ther
January 2025
Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
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