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Integrated care management for patients following acute stroke: a systematic review.
QJM
January 2025
School of Nursing and Advanced Practice, Liverpool John Moores University, Liverpool, United Kingdom.
Background: Contemporary stroke care is moving towards more holistic and patient-centred integrated approaches, however, there is need to develop high quality evidence for interventions that benefit patients as part of this approach.
Aim: This study aims to identify the types of integrated care management strategies that exist for people with stroke, to determine whether stroke management pathways impact patient outcomes, and to identify elements of integrated stroke care that were effective at improving outcomes.
Design: Systematic review with meta-analysis.
ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2.
Biomark Res
January 2025
Department of Clinical Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Background: Lung cancer, particularly non-small cell lung cancer (NSCLC), has high recurrence rates and remains a leading cause of cancer-related death, despite recent advances in its treatment. Emerging therapies, such as chimeric antigen receptor (CAR)-T cell therapy, have shown promise but face significant challenges in targeting solid tumors. This study investigated the potential of combining receptor tyrosine kinase-like orphan receptor 1 (ROR1)-targeting CAR-T cells with ferroptosis inducers to promote ferroptosis of tumor cells and enhance anti-tumor efficacy.
View Article and Find Full Text PDFDevelopment of the AIIMS Bhopal Pre-sternal Keloid Scale (ABPSKS): A Tool for Assessing Severity and Comparing Treatment Outcomes.
Cureus
December 2024
Obstetrics and Gynaecology, All India Institute of Medical Sciences Bibinagar, Hyderabad, IND.
Pre-sternal keloids are a distinct clinicopathological entity differing in many ways from keloids occurring elsewhere, as there are differences in pathogenesis, clinical presentation, and management. We have reviewed commonly used assessment scales like the Vancouver Scar Scale, the Patient and Observer Scar Assessment Scale, and the Detroit Keloid Scale and identified some shortcomings in applying them in assessing pre-sternal keloids. Therefore, we developed the AIIMS Bhopal pre-sternal keloid scale (ABPSKS), a pre-sternal keloid-specific tool to enable the assessment of the severity of the disease, the efficacy of treatment, and the comparison of outcomes of different treatment modalities.
View Article and Find Full Text PDFFamilial analysis: pulmonary Birt-Hogg-Dubé syndrome in two siblings.
BMJ Case Rep
January 2025
Department of Respiratory and Critical Care Medicine, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China
Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant genetic disorder. This case report aims to increase awareness of pulmonary cystic lesions and BHDS in China by providing insights into the clinical features of this syndrome. We present two cases of BHDS from the same family.
View Article and Find Full Text PDFTularemia in a Psoriasis Patient on Biologic Therapy After Relocation to Western South Dakota.
S D Med
December 2024
Department of Internal Medicine, University of South Dakota Sanford School of Medicine.
Background: Francisella tularensis is an aerobic, gram negative coccobacillus bacterium that causes tularemia. F. tularensis spreads primarily through ticks, biting flies, droplet inhalation, contaminated mud or water, or infected animal bites, and it can survive in animal carcasses with the most common mode of transmission occurring via inoculation into the skin and inhalation/ingestion.
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