Public Health.

Background: Racial and ethnic minorities, including Hispanic/Latino, Asian American and Pacific Islander individuals, lack adequate representation in preclinical Alzheimer's disease (AD) trials. This study sought to examine the effectiveness of a culturally and linguistically appropriate community-based educational intervention in enhancing knowledge and awareness of the AHEAD 3-45 preclinical AD trial among underrepresented Filipino, Korean, and Hispanic/Latino Americans.

Method: With professional nursing and other partner organizations, we conducted 21 community-based educational sessions for underrepresented older adults of Filipino, Korean, and Hispanic/Latino backgrounds. In addition to sociodemographic data, we collected the 7-item Research Attitude Questionnaire (RAQ; Range 7-35) and a 6-item Knowledge Questionnaire about the AHEAD 3-45 preclinical AD trial (Range 0-6) before and after the educational intervention. Pre- and post-summary scores were generated for both assessments. Paired t-tests assessed changes in research attitudes and knowledge concerning the AHEAD 3-45 trial.

Result: Among 654 attendees of the educational interventions, 472 (72%) completed surveys (Table 1). Most were women (77%), immigrants (83%), and had a primary language other than English (70%). The average age was 59 (16) years. Survey responses were obtained in English (41%), Spanish (29%), and Korean (30%). The primary motivations reported by attendees for attending the event were gaining information (48%) and concerns about memory loss for self and/or family members (41%). Knowledge of the AHEAD 3-45 preclinical AD trial was significantly increased from a mean of 2.15 (SD 2.2) at baseline to 4.32 (SD 1.9) post-educational intervention (p < 0.0001, Table 2). Overall RAQ scores remained unchanged for the sample and among Filipino, Korean, and Hispanic/Latino American subgroups (Table 3A), the educational intervention had a positive impact on the research attitudes of attendees under 55 years old (Table 3B) CONCLUSION: Our findings indicate the potential effectiveness of culturally and linguistically tailored educational interventions in fostering increased awareness and knowledge of preclinical AD research among Filipino, Korean, and Hispanic/Latino Americans. However, this single intervention did not affect research attitudes overall or in different subgroups most relevant to the AHEAD 3-45 trial (55 years and older), underscoring the need for additional tailored strategies to enhance representation in preclinical Alzheimer's disease research.