Background: Physical exercise improves clinical state of patients with Parkinson's disease (PD), and evidence from experimental models suggests it has a potential to slow down the disease progression. Improved glucose metabolism as well as exerkines, bioactive molecules released into circulation with each exercise bout, contribute to the synchronized exercise-induced adaptive response at a systemic level. Our aim was to assess effects of exercise on clinical state and molecular changes in cerebrospinal fluid (CSF) and blood of patients with PD.
Methods: Patients with PD (H&Y score I-III, 9F/17M; age 63.3 ± 8.4yrs; BMI 26.5 ± 5.9kg/m) underwent supervised 4-month aerobic-strength training (3×1h/week). Clinical state (MDS-UPDRS), body composition (BIA/MRI), cognitive functions (CogState, ACE-R, TMT-A&B, DSST, RAVL test), VOmax (Rockport 1 mile walk test), muscle strength (dynamometry), resting metabolic rate, metabolic substrate flexibility (indirect calorimetry), and insulin sensitivity (euglycemic hyperinsulinemic clamp) were assessed and CSF was sampled by atraumatic lumbar puncture (in a subpopulation) before / after 4-month intervention. Extracellular vesicles (EVs) were isolated from serum and CSF by size exclusion chromatography (SEC). Proteomic analysis (mass spectrometry) of the samples is currently ongoing.
Results: Four-month aerobic-strength exercise improved or tended to improve clinical state (MDS-UPDRS, p<0.05), body composition (reduced: BMI, p = 0.007; body fat, p = 0.08; visceral fat, p = 0.038) and cognitive performance (ACE-R verbal production subscore, p = 0.029; psychomotor function, p = 0.04; visual learning & short-term memory, p = 0.009) in patients with PD. Training reduced circulating HbA1C, improved whole-body metabolic flexibility (substrate preference based on the substrate availability, the hallmark of healthy metabolism) and muscle strength (all p<0,05). Proteomic analysis of the samples obtained before and after training is in progress.
Conclusions: A relatively short aerobic-strength exercise has favorable effects on cognition and clinical state in patients with PD which could be, at least in part, related to the improvements in patients' physical fitness and metabolism. It is plausible to speculate that the specific training-induced changes in the proteome of CSF, blood and EVs could be involved in the adaptive response underlying the exercise-induced health benefits in PD.
Funding: APVV-20-0466, VEGA-2/0076/22, ADDIT-CE Horizon Europe 101087124.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/alz.089825 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
United States and European Union laws demand separate clinical studies in children as a condition for drugs' marketing approval. Justified by carefully framed pseudo-scientific wordings, more so the European Medicines Agency than the United States Food and Drug Administration, "Pediatric Drug Development" is probably the largest abuse in medical research in history. Preterm newborns are immature and vulnerable, but they grow.
View Article and Find Full Text PDFMedical Termination of Pregnancy: Law and Controversies in the United States and Australia.
J Law Med
November 2024
Barrister, Castan Chambers, Melbourne, Australia; Professor of Law and Professorial Fellow in Psychiatry, University of Melbourne; Honorary Professor of Forensic Medicine, Monash; Adjunct Professor, Southern Cross University.
This editorial reviews the changes over two decades in the United States and Australia in relation to the law governing access to drugs enabling medical termination of pregnancy. It also scrutinises three contentious decisions by the United States Supreme Court between 2022 and 2024 in relation to abortion. It argues that the receptive environment in the United States Supreme Court, as it is currently constituted, to challenges to the lawfulness of terminations of pregnancy and abortion medications is likely to inspire comparable challenges as part of the "Abortion Wars" in other countries, including Australia.
View Article and Find Full Text PDFImplementation of a program to strengthen oral hygiene in patient with cleft deformities: a prospective randomized controlled clinical trial.
Trials
January 2025
INSERM, Regenerative Medicine and Skeleton, RMeS, CHU Nantes, Nantes Université, UMR 1229, Nantes, 44000, France.
Background: Cleft lip and/or palate is the most common congenital orofacial deformity, affecting 1/800 births. A thorough review of the literature has shown that children with cleft have poorer oral hygiene and dental health than other children, with higher levels of caries in both temporary and permanent teeth and poorer periodontal health. Cleft patients are treated by a multidisciplinary team that aims to provide comprehensive care from pre- or post-natal diagnosis to early adulthood and the end of growth.
View Article and Find Full Text PDFEvaluation of a national framework for rational use of medicines in Kazakhstan and its role in improving medicine use practices at the organizational and national levels.
BMC Health Serv Res
January 2025
Department of Clinical Pharmacology and Evidence-Based Medicine, NCJSC "Karaganda Medical University", 40, Gogolya St, Karaganda, 100000, Kazakhstan.
Background: Kazakhstan inherited the Semashko health system model, known for the centralized adoption of rules at the Ministry of Health (MoH) level that regulate the healthcare system. In 2019 MoH established a national framework with indicators aimed at collecting qualitative and quantitative data from healthcare organizations as part of their annual self-evaluation, and biannual external evaluation by the National Research Center for Health Development (NRCHD). The purpose of this study was to pilot the MoH framework on rational use of medicines and evaluate its effects on medicine use practices in health care organizations and at the national level.
View Article and Find Full Text PDFPlasma S100β is a predictor for pathology and cognitive decline in Alzheimer's disease.
Fluids Barriers CNS
January 2025
Sanders-Brown Center on Aging, College of Medicine, University of Kentucky, 760 Press Ave, 124 HKRB, Lexington, KY, 40536-0679, USA.
Background: Blood-brain barrier dysfunction is one characteristic of Alzheimer's disease (AD) and is recognized as both a cause and consequence of the pathological cascade leading to cognitive decline. The goal of this study was to assess markers for barrier dysfunction in postmortem tissue samples from research participants who were either cognitively normal individuals (CNI) or diagnosed with AD at the time of autopsy and determine to what extent these markers are associated with AD neuropathologic changes (ADNC) and cognitive impairment.
Methods: We used postmortem brain tissue and plasma samples from 19 participants: 9 CNI and 10 AD dementia patients who had come to autopsy from the University of Kentucky AD Research Center (UK-ADRC) community-based cohort; all cases with dementia had confirmed severe ADNC.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!