Background: Dementia is a heterogeneous syndrome caused by diseases that impact cerebral functioning leading to progressive cognitive decline and loss of functional independence. Approximately 55 million people worldwide are living with dementia; however, population-based estimates of dementia are challenging due to non-standardized surveillance in most countries. We estimated the number of dementia cases among Canadian residents in 2022.
Method: To create age-specific estimates of dementia in Canada, we compiled data from Statistics Canada. These data included the 2021 Canadian Census (to estimate the total population and type of residence-institutionalized vs. non-institutionalized), the 2019/2020 Canadian Community Health Survey (to estimate the number of non-institutionalized persons with dementia), and the 2013 Survey of Neurological Conditions in Institutions in Canada (to estimate the number of institutionalized persons with dementia). These data were used to compute estimates of the number of persons with dementia by age group (65-69, 70-74, 75-79, 80-84, 85-89, 90+) in Canada in 2022. Using the overall Canadian population estimates for these age groups, we then calculated age-specific estimates of dementia per 100,000 persons.
Result: In 2022, approximately 364,280 individuals 65+ years in Canada were living with dementia and the prevalence increased by age. Among those 65-69 years the estimated prevalence of dementia was 1,343 per 100,000 persons and increased to 25,350 per 100,000 persons among those 90+ years. The prevalence of dementia in non-institutionalized Canadians 65+ years was approximately 2.1%, and the prevalence among institutionalized Canadians was 52.5%. Of those with dementia, 41% were non-institutionalized and 59% institutionalized. The proportion of non-institutionalized dementia cases exceeded the institutionalized cases among those younger than 80 years (65% vs. 35%); however, for those 80+ years, there was a higher proportion of institutionalized cases compared with non-institutionalized cases (71% vs. 29%).
Conclusion: Dementia is a substantial source of morbidity in Canada, with increasing prevalence in an aging population. Standardized surveillance is necessary to understand the needs of this growing patient population, which would lead to more reliable estimates and allow for proper allocation of resources to improve care.
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http://dx.doi.org/10.1002/alz.089492 | DOI Listing |
Fluids Barriers CNS
January 2025
Sanders-Brown Center on Aging, College of Medicine, University of Kentucky, 760 Press Ave, 124 HKRB, Lexington, KY, 40536-0679, USA.
Background: Blood-brain barrier dysfunction is one characteristic of Alzheimer's disease (AD) and is recognized as both a cause and consequence of the pathological cascade leading to cognitive decline. The goal of this study was to assess markers for barrier dysfunction in postmortem tissue samples from research participants who were either cognitively normal individuals (CNI) or diagnosed with AD at the time of autopsy and determine to what extent these markers are associated with AD neuropathologic changes (ADNC) and cognitive impairment.
Methods: We used postmortem brain tissue and plasma samples from 19 participants: 9 CNI and 10 AD dementia patients who had come to autopsy from the University of Kentucky AD Research Center (UK-ADRC) community-based cohort; all cases with dementia had confirmed severe ADNC.
Alzheimers Res Ther
January 2025
Laboratory for Clinical Neuroscience, Center for Biomedical Technology, Universidad Politécnica de Madrid, IdISSC, Crta M40, km38, Madrid, 28223, Spain.
Background: Dementia patients commonly present multiple neuropathologies, worsening cognitive function, yet structural neuroimaging signatures of dementia have not been positioned in the context of combined pathology. In this study, we implemented an MRI voxel-based approach to explore combined and independent effects of dementia pathologies on grey and white matter structural changes.
Methods: In 91 amnestic dementia patients with post-mortem brain donation, grey matter density and white matter hyperintensity (WMH) burdens were obtained from pre-mortem MRI and analyzed in relation to Alzheimer's, vascular, Lewy body, TDP-43, and hippocampal sclerosis (HS) pathologies.
BMC Public Health
January 2025
National Institute for Public Health and the Environment, Center for Prevention, Lifestyle and Health, Department Behaviour and Health, Antonie van Leeuwenhoeklaan 9, Bilthoven, 3721 MA, The Netherlands.
Background: Many organizations are faced with growing numbers of employees who combine their jobs with informal caregiving responsibilities. To support working caregivers in maintaining a good balance between work, private life and informal care, a workplace participatory approach (PA) intervention was implemented in four Dutch organizations. This study's aims were to evaluate the degree of PA implementation, contextual factors influencing implementation, and stakeholder experiences with the PA.
View Article and Find Full Text PDFBMC Geriatr
January 2025
International Observatory on End of Life Care, Lancaster University, Lancaster, UK.
Background: Namaste Care is an intervention designed to improve the quality of life for people with advanced dementia by providing individualised stimulation and personalised activities in a group setting. Current evidence indicates there may be benefits from this intervention, but there is a need to explore the practical realities of its implementation, including potential barriers, enablers, and how it is delivered within the context of nursing care homes.
Objective: To systematically assess the factors involved in implementing Namaste Care for people with advanced dementia in nursing care homes.
Neurosurg Rev
January 2025
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Objective: Dural arteriovenous fistulas (DAVFs) with deep venous drainage (DVD) (DAVFs-DVD) are characteristically associated with non-hemorrhagic neurological deficits, most notably cognitive impairment. Large studies have yet to thoroughly characterize these DAVFs. We conducted an analysis of the largest cohort of DAVFs-DVD to provide a comprehensive characterization of this specific subset.
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