The duodenal diverticulum is a relatively frequent entity whose diagnosis has been increased over time with the development of new diagnostic and exploratory techniques. Periampullary diverticula (PAD) were classified as type 1, 2, or 3 according to the position of the major papilla from the endoscopic view: type 1, the major papilla was located inside of the diverticula; type 2, the major papilla was located at the edge of the diverticula; type 3, the major papilla was located outside of the diverticula. Complications of duodenal diverticula include ulceration, bleeding, perforation and inflammation with intestinal obstruction. Perforation of duodenal diverticula due to both local ischemia or mechanical obstruction, is exceedingly rare, however, this entity has a high associated mortality. Duodenal perforations can either be free or contained. The optimal management of which has not been well established. We describe the case of a 61-year-old male with a diagnosis of acute pancreatitis due to abdominal pain, elevation of pancreatic enzymes and computed tomography (CT) findings of inflammatory peri and pancreatic changes. However, he presented a severe elevation of acute phase reactants and poor control of the pain. Given lack of improvement, the abdominal CT was repeated and revealed a probable perforation of the duodenal diverticulum with local inflammatory changes which would explain the elevation of pancreatic enzymes but the lack of response to treatment. With the new diagnosis of duodenal diverticulum and spontaneous perforation, evaluation was performed with General Surgery indicating conservative management. Absolute diet, parenteral nutrition and empirical antibiotic therapy with ciprofloxacin and metronidazole were started with improvement, allowing the progressive reintroduction of the diet, being well tolerated. Analytically and radiologically improvement was finally also observed.
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http://dx.doi.org/10.17235/reed.2024.10955/2024 | DOI Listing |
Rev Esp Enferm Dig
January 2025
Digestive Diseases, Hospital Universitario Fundación Jiménez Díaz, España.
The duodenal diverticulum is a relatively frequent entity whose diagnosis has been increased over time with the development of new diagnostic and exploratory techniques. Periampullary diverticula (PAD) were classified as type 1, 2, or 3 according to the position of the major papilla from the endoscopic view: type 1, the major papilla was located inside of the diverticula; type 2, the major papilla was located at the edge of the diverticula; type 3, the major papilla was located outside of the diverticula. Complications of duodenal diverticula include ulceration, bleeding, perforation and inflammation with intestinal obstruction.
View Article and Find Full Text PDFSci Rep
December 2024
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
The morphology of the major duodenal papilla (MDP) plays a crucial role in the selection of the cannulation technique. Primary needle-knife fistulotomy (pNKF) is an advanced cannulation technique is getting more popular because of the lower risk of post-ERCP pancreatitis (PEP). However, few studies have explored the impact of MDP morphology on pNKF outcomes.
View Article and Find Full Text PDFInt J Nanomedicine
December 2024
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong Province, People's Republic of China.
Introduction: Alopecia is a systemic disease with multiple contributing factors. Effective treatment is challenging when only hair growth mechanisms are targeted while ignoring the role of maintaining hair follicle microenvironment homeostasis, which is crucial for cell growth and angiogenesis. Oxidative stress and inflammation are major disruptors of this microenvironment, leading to inhibited cell proliferation and compromised hair follicle circulation.
View Article and Find Full Text PDFMicrosc Res Tech
December 2024
Laboratory of Entomology, Institute of Zoology of the Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.
Ascariasis, caused by the parasitic roundworm Ascaris lumbricoides, is a major public health issue, especially in developing nations such as Pakistan. It impacts millions, causing significant morbidity through starvation, stunted growth in children, and a variety of gastrointestinal issues. The taxonomy of the Ascaris genus, notably the distinction between A.
View Article and Find Full Text PDFJ Anim Physiol Anim Nutr (Berl)
December 2024
Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Wool traits determine the market value of fine-wool sheep, and wool fibre-breaking elongation (fibres can be stretched or elongated before they break) is one of the important wool traits. The interaction between hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs) determines hair follicle development in fine wool sheep, thereby directly influencing wool traits. A genome-wide association study based on pre-sequencing data identified FGF20, which was significantly associated with wool fibre-breaking elongation.
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