Background: Alzheimer's disease (AD) therapy requires timely and accurate diagnosis for prompt drug intervention, emphasizing the need for a more accessible biomarker screening test. Previous studies identified higher expression of oligomeric Aβ in AD patients, however, the quantitative measurements of nasal Aβ42 levels of the full AD continuum remain unknown.
Method: We collected nasal discharge samples from 161 subjects who underwent neuropsychological battery tests and amyloid-PET and nasal Aβ42 levels were measured via enzyme-linked immunosorbent assay (ELISA).
Result: Our results revealed that the second-highest quartile (Q3) group of nasal Aβ42 had the majority of patients with AD diagnosis, and those in the Q3 group exhibited the most impaired cognitive function with a strong significance. Nasal Aβ42 levels were also associated with brain amyloid PET results and increased risk of developing AD.
Conclusion: Our findings suggest that nasal Aβ42 is a promising biomarker for AD diagnosis and risk assessment.
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http://dx.doi.org/10.1002/alz.094935 | DOI Listing |
BMC Musculoskelet Disord
January 2025
Department of Health Sciences, Faculty of Medicine, Lund University, Box 117, Lund, 221 00, Sweden.
Background: Osteoarthritis (OA) often leads to pain and functional limitations, impacting work and daily life. Physical activity (PA) is an important part of the treatment. Wearable activity trackers (WATs) offer a novel approach to promote PA but could also aid in finding a sustainable PA level over time.
View Article and Find Full Text PDFBMC Cancer
January 2025
Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
BMC Pregnancy Childbirth
January 2025
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Background: Vaginal colonization by Candida can lead to vulvovaginal candidiasis, which is the second most prevalent vaginal condition globally. It is frequently associated with sepsis and adverse neonatal outcomes in pregnant women. This issue is worsening in Sub-Saharan Africa, including Ethiopia.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Currently, the direct endonasal approach is widely used in endoscopic endonasal surgery (EES) for pituitary neuroendocrine tumor. However, a large posterior septal perforation is inevitable. We routinely utilize a modified para/transseptal approach using the combination of a Killian and a contralateral rescue flap incision (PTSA with K-R incision).
View Article and Find Full Text PDFJ Plast Reconstr Aesthet Surg
October 2023
State Key Laboratory of Oral Diseases and National Clinical Research Centre for Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address:
Background: Improving growth-related nasal stability is a critical goal of primary cleft lip repair. The purpose of this study was to evaluate the growth-related stability of the nose after unilateral complete cleft lip (UCCL) repair with standard rotation-advancement (RA) and modified rotation-advancement (MRA) techniques.
Material And Method: In this retrospective study, 52 non-syndromic (UCCL) patients were treated with a MRA technique, where a C-flap and a superiorly based advanced flap were used to lengthen and support the columella and nasal sill, and 48 patients were treated with a standard RA technique.
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