Background: The Internal Jugular Veins (IJVs) and the non-jugular veins (NJVs) are two pathways responsible for intracranial blood drainage. The NJVs are usually the less prominent drainage system and have been demonstrated to become smaller during aging. This phenomenon may indicate less affective venues drainage and hence less CNS's waste products clearance as we age. One of the pathological hallmarks in Alzheimer's disease (AD) is amyloid betta42 (AB42) accumulation. AB42 accumulation may be the result of overproduction or clearance impairment. NJVs narrowing during aging may cause AB42 accumulation due to clearance impairment and hence plays a role in AD pathology. Our aim was to compare the venous cross-sectional area (CSA) in AD vs. cognitive normal (CN) population.
Method: Cognitive impaired patients included AD and mild cognitive impairment (MCI) patients that were recruited prospectively as part of the DIASPORA Horizon-2020 MesCobrad Project. All patients performed comprehensive neurocognitive evaluation and Brain MRI including Time-of-flight sequence for venous demonstration. Venous systems CSA were measured at the jugular foramen level and were done by senior neuroradiologist. CN were defined as subjects without CNS's known pathology. CN Measurements were taken from a previous study of our group. T-test was used to compare between groups.
Result: A total of 39 Cognitive impaired patients and 20 CN were included in the study. Mean ages of 68 years (SD, 5.4) and 66 years (SD, 5.5), respectively. The CSA of the IJVs was similar between groups. However, NJVs CSA was significantly smaller in cognitive impaired patients (mean CSA=41.21 mm2 (SD,21.52) vs. CSA=54.5 mm2 (SD,27.3) P=0.045). Table 1.
Conclusion: NJVs are significantly smaller in cognitive impaired patients compared to CN population. NJVs narrowing in AD patients may cause impaired venous drainage hence causing AB42 accumulation in this population. New treatment options for AD patients may rise if larger studies replicate our findings.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/alz.093759 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomarkers.
Alzheimers Dement
December 2024
Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
Background: Alzheimer's disease (AD) blood biomarkers alone can detect amyloid-β (Aβ) pathology in cognitively unimpaired (CU) individuals. We assessed whether combining different plasma biomarkers improves the detection of Aβ-positivity and identifies rapid amyloid deposition in CU individuals.
Method: CU participants from the ALFA+ cohort were included.
Biomarkers.
Alzheimers Dement
December 2024
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Background: The buildup of brain amyloid-beta and tau protein aggregates do not sufficiently explain the heterogeneity in cognitive impairment in Alzheimer's disease (AD).
Method: To elucidate drivers of cognitive impairment, we measure the levels of 7,000 proteins, in addition to amyloid-beta-42 (Ab42) and phospho-tau-181 (PTau181), from the cerebrospinal fluid of 2,000 individuals from healthy to severe dementia.
Result: We identify synapse proteins as the strongest correlates of cognitive impairment.
Background: The choroid plexus plays an important role in the pathophysiology of Alzheimer's disease (AD) and in immune surveillance. Neuroinflammation is known to occur in the early stages of AD, where amyloid accumulation leads to cognitive decline in later stages. However, the relationship between choroid plexus volume (ChPV) and cerebrospinal fluid (CSF) inflammatory markers, amyloid burden and cognitive decline in vivo remains underexplored.
View Article and Find Full Text PDFBackground: The Internal Jugular Veins (IJVs) and the non-jugular veins (NJVs) are two pathways responsible for intracranial blood drainage. The NJVs are usually the less prominent drainage system and have been demonstrated to become smaller during aging. This phenomenon may indicate less affective venues drainage and hence less CNS's waste products clearance as we age.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
Rabin medical center, Petach Tikva, Israel.
Background: The Internal Jugular Veins (IJVs) and the non-jugular veins (NJVs) are two pathways responsible for intracranial blood drainage. The NJVs are usually the less prominent drainage system and have been demonstrated to become smaller during aging. This phenomenon may indicate less affective venues drainage and hence less CNS's waste products clearance as we age.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!