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Alzheimers Dement
December 2024
Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Background: Alzheimer's disease (AD) and related dementias can have long preclinical phases; thus, midlife intervention and prevention methods could prove efficacious. Multiple health-related lifestyle factors have been associated with risk for AD. However, research on lifestyle factors has focused on clinical outcomes such as cognitive decline, mild cognitive impairment and/or AD dementia; their associations with potential early changes in cerebrospinal fluid (CSF) biomarkers are less understood.
View Article and Find Full Text PDFBackground: Individuals with his parents having Alzheimer's dementia (AD) have a 4 to 10 times higher risk of developing AD compared to those without family history. The increasing risks of developing AD may result from several underlying mechanisms to be clarified for further strategies of management. We are going to report the demographic and biological characteristics of adult children (AC) of AD parents cohort with its clinical significances in Taiwan.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is identified by the accumulation of amyloid β (Aβ) and tau proteins in the brain. The NeuroToolKit offers automated cerebrospinal fluid (CSF) immunoassays of core AD biomarkers and biomarkers of neurodegeneration and synaptic function, including neurofilament light (NfL), SNAP-25, and neuronal pentraxin 2 (NPTX2). This work explores whether these three markers predict pre-dementia cognitive decline synergistically with or after accounting for CSF ptau/Aβ.
View Article and Find Full Text PDFBackground: Timely post-diagnostic support is necessary to assist people living with dementia and their families to preserve their independence and to facilitate emotional and practical adaptation to dementia diagnosis and life after diagnosis. However, there is a noticeable scarcity of evidence concerning support following dementia diagnosis. Our objective was to examine the following aspects: the nature and type of evidence pertaining to post-diagnostic support within the initial two years of diagnosis; the conceptualization of post-diagnostic support; and the existing gaps in the literature concerning this essential support.
View Article and Find Full Text PDFResistance-associated substitutions (RASs) are mutations within the hepatitis C (HCV) genome that may influence the likelihood of achieving a sustained virological response (SVR) with direct acting antiviral (DAA) treatment. Clinicians conduct RAS testing to adapt treatment regimens with the intent of improving the likelihood of cure. The Canadian Network Undertaking against Hepatitis C (CANUHC) prospective cohort consists of chronic HCV patients enrolled between 2015 and 2023 across 17 Canadian sites.
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