A 6-year-old Labrador retriever dog with a history of pneumonia was presented because of an acute onset of dull mentation and coughing. Diagnostic imaging and cytology revealed a pneumothorax, pneumomediastinum, and pleural effusion, consistent with pyothorax. The dog underwent exploratory sternotomy for lung lobectomy of the right cranial and middle lung lobes. Persistent pneumothorax and pleural effusion were present after surgery, and the sternotomy site dehisced 6 d postoperatively. A second CT scan revealed persistent consolidation of the left cranial lung lobe and continued pneumothorax and pleural effusion. A left cranial lung lobectomy was done on the 8th day following initial surgery. An incisional infection was determined to be associated with multidrug-resistant infection. Due to persistent pleural and incisional drainage, a third exploratory sternotomy was required, which revealed dehiscence of the surgical site and an unstable sternal repair with fractured sternebrae. The sternotomy site was left partially closed and negative pressure wound therapy (NPWT) was applied. No complications with NPWT were encountered, and the incision healed appropriately. Key clinical message: This is the first documented description of the use of NPWT in a dog to successfully manage a partially closed sternotomy and resolve a multidrug-resistant infection of the sternotomy site.
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Can Vet J
January 2025
Veterinary Clinical Sciences Department, College of Veterinary Medicine, University of Minnesota, 1352 Boyd Avenue, St. Paul, Minnesota 55108, USA.
A 6-year-old Labrador retriever dog with a history of pneumonia was presented because of an acute onset of dull mentation and coughing. Diagnostic imaging and cytology revealed a pneumothorax, pneumomediastinum, and pleural effusion, consistent with pyothorax. The dog underwent exploratory sternotomy for lung lobectomy of the right cranial and middle lung lobes.
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January 2025
General Surgery, Womack Army Medical Center, Fort Liberty, USA.
This case report presents a unique clinical presentation of small bowel obstruction secondary to congenital partial malrotation of the gut in adults. Partial malrotation may have variable clinical presentations and this case highlights a constellation of patient history, radiographic signs, and operative findings leading to appropriate diagnosis and successful surgical management. A 56-year-old female patient presented with severe abdominal pain, nausea, and anorexia.
View Article and Find Full Text PDFJ Integr Plant Biol
January 2025
State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, College of Agriculture, Nanjing Agricultural University, Nanjing, 210095, China.
Members of the cyclic nucleotide-gated channel (CNGC) proteins are reportedly involved in a variety of biotic and abiotic responses and stomatal movement. However, it is unknown if and how a single member could regulate multiple responses. Here we characterized three closely related CNGC genes in rice, OsCNGC14, OsCNGC15 and OsCNGC16, to determine whether they function in multiple abiotic stresses.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Biology, College of Chemistry & Life Science, Beijing University of Technology, Chaoyang, Beijing, China.
Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer, characterized by a high incidence in late stages, high mortality rate, and poor prognosis. Src Homology 2 Domain Containing Protein 5 (SH2D5) is a mammalian-specific, uncharacterized scaffolding protein, and its role in LUAD remains unclear. In the present study, we investigated the function and potential mechanisms of SH2D5 in the progression of LUAD.
View Article and Find Full Text PDFMicroorganisms
December 2024
Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Tetanus neurotoxins (TeNT) and botulinum neurotoxins (BoNTs) are closely related ~150 kDa protein toxins that together comprise the group of clostridial neurotoxins (CNTs) expressed by various species of . While TeNT is expressed as a single polypeptide, BoNTs are always produced alongside multiple non-toxic proteins that form a stabilizing complex with BoNT and are encoded in a conserved toxin gene cluster. It is unknown how evolved without a similar gene cluster and why complex-free TeNT is secreted as a stable and soluble protein by , whereas complexing proteins appear to be essential for BoNT stability in culture supernatants of .
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