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| http://dx.doi.org/10.1093/rap/rkae153 | DOI Listing |
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Mood Alterations in the Prodromal Phase of Sporadic Creutzfeldt-Jakob Disease.
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December 2024
Department of Neurology, Medical University of Vienna, Vienna, Austria.
Importance: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare, rapidly progressive and fatal neurodegenerative disease. Definite sCJD diagnosis can only be made post mortem, and little is known about the prodromal phase of the disease.
Objective: To compare drug prescription patterns before the clinical onset of sCJD between patients and matched controls for exploration of potential risk factors and to assess correlations between drug exposure and sCJD survival.
Background: Prostatic malignancy with paraneoplastic subacute encephalitis -A rare syndrome METHOD: We present a case of 76 year old male without any previous comorbidity and addiction who manifested a rapid neuropsychiatric decline with a frontotemporal syndrome over a period of 6 months. He was anemic and cerebrospinal fluid study showed 10 cells with lymphocytic predominance. The extensive workup of csf for infection, malignancy revealed nothing.
View Article and Find Full Text PDFBackground: Enriching and detecting Alzheimer's disease (AD) biomarkers in cerebral spinal fluid (CSF) or blood samples are increasingly applied in the AD diagnosis and monitoring of disease progression and treatment response. The accuracy of these processes is dependent on the sensitivity and specificity of capturing and quantifying AD biomarkers, e.g.
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National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
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Peking Union Medical College, Beijing, Beijing, China.
Background: With a rapidly aging population, general practitioners (GPs) in communities are confronting the challenge of determining those who are at greatest risk for cognitive impairment and potentially need more specialized follow-up and intervention to mitigate symptoms early in their course. Mild cognitive impairment (MCI) serves as an important stage for the early intervention and prevention of dementia. However, most MCI survey questionnaires require heavy investments of manpower and time, which limits the possibility of their application among GPs in communities.
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