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We need evidence-based futility thresholds to transplant grade-3 acute on chronic liver failure patients with poor respiratory, haemodynamic, and metabolic parameters.
Lancet Reg Health Eur
February 2025
Azienda Ospedale Università di Padova, Unità Trapianto Multiviscerale, Gastroenterologia, Padua, Italy.
Therapeutic effect of coenzyme-Q10 pretreatment on isoprenaline-induced cardiogenic hepatorenal complications in rats.
Int J Physiol Pathophysiol Pharmacol
December 2024
Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, Delta State University Abraka, Nigeria.
Objectives: The significant correlation between acute myocardial infarction and subsequent hepatorenal dysfunction could result in a higher mortality rate in patients. The study aimed to evaluate the effect and mechanisms of coenzyme-Q10 (Q10) administration on hepatorenal dysfunction in an isoprenaline (ISO)-induced myocardial infarction model in rats.
Materials And Methods: Twenty male rats were assigned into four groups (n = 5).
Inpatient complications and mortality in cirrhotic patients undergoing bariatric surgery: a comprehensive analysis.
Hosp Pract (1995)
January 2025
Pulmonary and Critical Care Medicine, University of Toledo, Toledo, OH, USA.
Introduction: Liver cirrhosis, a complex and progressive disease,imposes a significant global health burden, characterized by irreversible livertissue scarring and various life-threatening complications. Traditionallylinked to factors like chronic alcohol consumption and viral hepatitisinfections, the rising prevalence of obesity introduces a new dimension to itsetiology. As obesity rates continue to climb worldwide, the confluence of livercirrhosis and bariatric surgery has become an increasingly pertinent andclinically relevant topic of inquiry.
View Article and Find Full Text PDFAcute arsenic exposure induces cyto-genotoxicity and histological alterations in Labeo rohita.
J Trace Elem Med Biol
January 2025
Department of Fisheries and Aquaculture, University of Veterinary and Animal Sciences, Lahore, Pakistan. Electronic address:
Background: Arsenic emerges as most potent hazardous element ranked as number one in ATSDR (Agency for Toxic Substances and Disease Registry) list, can easily accumulate in fish, transported to humans via consumption and affect humans and aquatic organisms. Considering above, current experiment designed to evaluate cyto-genotoxicity and histological alterations induced by arsenic in Labeo rohita used as an animal model.
Methods: By applying complete randomized design sampling acclimatized individuals of Labeo rohita (10 batches of 10 each with triplicates) were exposed to nine definitive doses (12, 14, 16, 18, 20, 22, 24, 26 and 28 mgL) of arsenic in glass aquaria to determine 96-h lethal concentration (LC) of arsenic.
Design, Synthesis, and Evaluation of Selective PDE4 Inhibitors for the Therapy of Pulmonary Injury.
J Med Chem
January 2025
Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, Guangdong 510260, China.
Pulmonary inflammation is the main cause of lung injury. Phosphodiesterase 4 (PDE4) is a promising anti-inflammatory target for the treatment of respiratory diseases. Herein, we designed and synthesized 43 compounds in two novel series of benzimidazole derivatives as PDE4 inhibitors.
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