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Angiogenesis as a Survival Mechanism in Heartworm Disease: The Role of Fructose-Bisphosphate Aldolase and Actin from in an In Vitro Endothelial Model.
Animals (Basel)
November 2024
Zoonotic Diseases and One Health Group, Faculty of Pharmacy, Biomedical Research Institute of Salamanca (IBSAL), Centre for Environmental Studies and Rural Dynamization (CEADIR), University of Salamanca, 37007 Salamanca, Spain.
Heartworm disease, caused by is a vector-borne zoonotic disease, (mainly affecting canids and felids) causing chronic vascular and pulmonary pathology in its early stages, which worsens with parasite load and/or death of adult worms in the pulmonary artery or right heart cavity, and can be fatal to the host. Angiogenesis is a mechanism by which new blood vessels are formed from existing ones. The aim of this work was to study the effect of two molecules of the excretory/secretory antigen (DiES) on the angiogenic process, taking into account that this antigen is able to interact with this process and use it as a survival mechanism.
View Article and Find Full Text PDFAuthentication of Honey from the Middle Atlas Mountains of Morocco: Physicochemical Properties, Mineral Content, Sugar, Polyphenol Profiles, and Antioxidant Capacity.
ACS Omega
November 2024
Bioactive and Environmental Health Laboratory, Moulay Ismail University, Faculty of Sciences, Meknes 50000, Morocco.
The jujube honey from the Moroccan Middle Atlas area is thoroughly described in this study, which takes into account melissopalynological, physicochemical, antioxidant, mineral, and phytochemical characteristics. Twelve samples of jujube honey underwent in-depth analyses between 2019 and 2021. The honey's unifloral origin was confirmed by pollen analysis, which revealed that pollen predominated along with pollen from 21 other species.
View Article and Find Full Text PDFIdentification and characterization of the spore germination protein GerY.
J Bacteriol
December 2024
Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA.
Article Synopsis
- Endospore-forming bacteria can survive prolonged starvation by entering a dormant state as spores, which can remain inactive for years but can quickly resume growth when nutrients are available.
- Researchers used transposon-sequencing to identify genes involved in spore germination, discovering both known and new germination genes; they provided detailed characterization of 15 genes, focusing on one key protein, GerY.
- Findings suggest that proteins like GerY, GerT, and GerP are crucial for nutrient transit through the spore coat to activate germination, highlighting their independent roles in the germination process.
Diet acts on sexual behavior development in a male moth.
Insect Sci
October 2024
Sorbonne Université, Université Paris-Est Créteil, INRAE, CNRS, IRD, Institute for Ecology and Environmental Sciences of Paris, iEES Paris, Versailles, France.
In many animals, drastic changes are observed during sexual maturation characterized by the reproductive system development concomitantly to the sexual behavior ontogenesis. These modifications are under the control of internal and external factors such as food. Sexual maturation requires considerable energetic investment, and diet has been shown to affect reproductive activities in many taxonomic groups, especially in insects and vertebrates.
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