Skin cancer is common and deadly, hence a correct diagnosis at an early age is essential. Effective therapy depends on precise classification of the several skin cancer forms, each with special traits. Because dermoscopy and other sophisticated imaging methods produce detailed lesion images, early detection has been enhanced. It's still difficult to analyze the images to differentiate benign from malignant tumors, though. Better predictive modeling methods are needed since the diagnostic procedures used now frequently produce inaccurate and inconsistent results. In dermatology, Machine learning (ML) models are becoming essential for the automatic detection and classification of skin cancer lesions from image data. With the ensemble model, which mix several ML approaches to take use of their advantages and lessen their disadvantages, this work seeks to improve skin cancer predictions. We introduce a new method, the Max Voting method, for optimization of skin cancer classification. On the HAM10000 and ISIC 2018 datasets, we trained and assessed three distinct ML models: Random Forest (RF), Multi-layer Perceptron Neural Network (MLPN), and Support Vector Machine (SVM). Overall performance was increased by the combined predictions made with the Max Voting technique. Moreover, feature vectors that were optimally produced from image data by a Genetic Algorithm (GA) were given to the ML models. We demonstrate that the Max Voting method greatly improves predictive performance, reaching an accuracy of 94.70% and producing the best results for F1-measure, recall, and precision. The most dependable and robust approach turned out to be Max Voting, which combines the benefits of numerous pre-trained ML models to provide a new and efficient method for classifying skin cancer lesions.
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http://dx.doi.org/10.1038/s41598-024-84864-5 | DOI Listing |
Gynecol Oncol Rep
February 2025
People's Hospital of China Medical University, Department of Gynecology, People's Hospital of Liaoning Province, Shenyang, China.
Background: Keratoacanthoma is a relatively rare skin tumor, with vulvar keratoacanthoma being even more uncommon. Although the majority of keratoacanthomas exhibit a benign course, a subset of cases may show features of malignant potential, such as marginal invasion and recurrence.
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Indian Dermatol Online J
December 2024
Department of Dermatology, Father Muller Medical College, Mangalore, Karnataka, India.
Microcystic adnexal carcinoma (MAC) is a rare, slow-growing, locally aggressive malignant, and recurring appendageal tumor. Prolonged UV exposure, immunosuppression, and radiotherapy are a few frequently associated risk factors. MAC classically presents as an asymptomatic skin coloured plaque on the face.
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January 2024
Mr. Davidson is with Fallon Medica in Tinton Falls, New Jersey, and was an employee of Bristol Myers Squibb at the time of manuscript development.
Numerous clinical trials have established that various biologic and oral small-molecule therapies are efficacious in patients with psoriasis. However, as there are limited head-to-head trials, healthcare providers may compare results across multiple trials when providing treatment recommendations. Direct comparisons among agents are challenging because psoriasis trials differ in terms of study design, patient population, and data analysis methodologies.
View Article and Find Full Text PDFImmunohorizons
January 2025
Vaccine Research & Development Center, Department of Physiology & Biophysics, University of California Irvine, Irvine, CA 92697, United States.
Adjuvants play a central role in enhancing the immunogenicity of otherwise poorly immunogenic vaccine antigens. Combining adjuvants has the potential to enhance vaccine immunogenicity compared with single adjuvants, although the cellular and molecular mechanisms of combination adjuvants are not well understood. Using the influenza virus hemagglutinin H5 antigen, we define the immunological landscape of combining CpG and MPLA (TLR-9 and TLR-4 agonists, respectively) with a squalene nanoemulsion (AddaVax) using immunologic and transcriptomic profiling.
View Article and Find Full Text PDFPol J Pathol
January 2025
Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
Multinucleate cell angiohistiocytoma (MCAH) is a rare benign cutaneous entity. It classically presents as slowly progressive erythematous to violaceous papules on the distal extremities of middle-aged or elderly women. The entity may clinically resemble granuloma annulare, lichen planus, and several cutaneous vascular proliferations.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!