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Assessing plasmatic transport inhibitors of thyroid hormone in mammals in the Xenopus Eleutheroembryonic Thyroid Assay (XETA).
Environ Sci Pollut Res Int
November 2024
BASF SE, Agricultural Solutions - Ecotoxicology, Speyerer Strasse 2, 67117, Limburgerhof, Germany.
The Xenopus Eleutheroembryonic Thyroid Assay (XETA, OECD TG 248) was established as an alternative to the Amphibian Metamorphosis Assay (AMA, OECD TG 231) for the analysis of (anti-)thyroid activity of chemicals. The XETA is a New Approach Method (NAM) since the embryonic life stages used in the assay are not yet feeding independently, which renders the assay to be considered a non-animal test under many national laws. Physiologically, the used embryos are not fully developed yet, and thus there are limitations to the XETA for detecting certain mechanisms along the hypothalamic-pituitary-thyroid (HPT) axis.
View Article and Find Full Text PDFRemoval mechanisms of pentachlorophenol in a horizontal-flow anaerobic immobilized biomass reactor (HAIB) inoculated with an indigenous estuarine sediment microbiota: adsorption and biodegradation processes.
Biodegradation
October 2024
Hydraulic and Sanitation Department, São Carlos College of Engineering, University of São Paulo, Avenida João Dagnone 1100, São Carlos, São Paulo, Brazil.
Article Synopsis
- * Adsorption was the main PCP removal mechanism, showing high efficiency (86-104%) at various concentrations, while biodegradation produced toxic intermediates, with significant bacterial community impacts noted.
- * Indigenous inoculum from the Santos-São Vicente estuary and polyurethane foam were effective in enhancing both the adsorption process and the overall PCP removal, without inhibiting microbial activity.
Polyethylene microplastic modulates the toxicity of pentachlorophenol to the microalgae Isochrysis galbana, clone t-ISO.
Chemosphere
November 2024
University of El Manar, Faculty of Sciences of Tunis, Department of Biology, Ecology, Biology and Physiology of Aquatic Organisms Laboratory, Tunis, Tunisia. Electronic address:
Article Synopsis
- Pentachlorophenol (PCP) and polyethylene microplastic (PE-MP) are recognized as new and persistent pollutants, and their combined effects on phytoplankton, specifically the microalgae Isochrysis galbana, have not been previously studied.
- The study found that exposure to PE-MP and PCP, both individually and together, inhibited the growth of Isochrysis galbana, with specific concentrations leading to significant decreases in vital cellular components such as photosynthetic pigments and proteins.
- Interestingly, at a non-toxic concentration of 25 mg/L, PE-MP appeared to lessen the harmful effects of PCP, likely by adsorbing the PCP and reducing its availability to the algal cells
Pentachlorophenol increases diabetes risk by damaging β-cell secretion and disrupting gut microbial-related amino acids and fatty acids biosynthesis.
J Hazard Mater
December 2024
Beijing Ctr Dis Prevent & Control, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing, PR China; Xihua Univ, Sch Food & Bioengn, Food Microbiol Key Lab Sichuan Prov, Chengdu 610039, PR China. Electronic address:
Article Synopsis
- * Animal experiments indicated that low doses of PCP can lead to pancreatic β-cell dysfunction and disrupt glycemic control, while also revealing non-linear dose-response relationships.
- * Additional analysis showed that PCP exposure alters gut microbiota and serum metabolites, suggesting that these changes might contribute to increased diabetes risk by affecting biosynthesis of amino acids and fatty acids in rats, paving the way for further research on PCP's impact on human diabetes.
Exploring the activation potential of heme for 2,4-dichlorophenol, 2,4,6-trichlorophenol, and pentachlorophenol.
Sci Rep
October 2024
School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421000, China.
The presence of chlorophenols in water poses a significant threat to human health and the environment. In response to this issue, a study was undertaken to evaluate the catalytic capabilities of chlorinated Heme towards common chlorophenols present in water, such as 2,4-dichlorophenol, 2,4,6-trichlorophenol, and pentachlorophenol. The study employed the B3LYP method, a sophisticated computational technique within density functional theory, to investigate the molecular interactions and transformations involved.
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